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Design and Synthesis of Enantiomerically Pure Decahydroquinoxalines as Potent and Selective κ-Opioid Receptor Agonists with Anti-Inflammatory Activity in Vivo.
Soeberdt M, Molenveld P, Storcken RP, Bouzanne des Mazery R, Sterk GJ, Autar R, Bolster MG, Wagner C, Aerts SN, van Holst FR, Wegert A, Tangherlini G, Frehland B, Schepmann D, Metze D, Lotts T, Knie U, Lin KY, Huang TY, Lai CC, Ständer S, Wünsch B, Abels C. Soeberdt M, et al. Among authors: wunsch b. J Med Chem. 2017 Mar 23;60(6):2526-2551. doi: 10.1021/acs.jmedchem.6b01868. Epub 2017 Mar 13. J Med Chem. 2017. PMID: 28218838
Methylated analogues of methyl (R)-4-(3,4-dichlorophenylacetyl)- 3-(pyrrolidin-1-ylmethyl)piperazine-1-carboxylate (GR-89,696) as highly potent kappa-receptor agonists: stereoselective synthesis, opioid-receptor affinity, receptor selectivity, and functional studies.
Soukara S, Maier CA, Predoiu U, Ehret A, Jackisch R, Wünsch B. Soukara S, et al. Among authors: wunsch b. J Med Chem. 2001 Aug 16;44(17):2814-26. doi: 10.1021/jm0108395. J Med Chem. 2001. PMID: 11495592
321 results