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Biotransformation of 4-fluoro-N-(1-{2-[(propan-2-yl)phenoxy]ethyl}-8-azabicyclo[3.2.1]octan-3-yl)-benzenesulfonamide, a novel potent 5-HT7 receptor antagonist with antidepressant-like and anxiolytic properties: In vitro and in silico approach.
Słoczyńska K, Wójcik-Pszczoła K, Canale V, Żmudzki P, Zajdel P, Pękala E. Słoczyńska K, et al. J Biochem Mol Toxicol. 2018 May;32(5):e22048. doi: 10.1002/jbt.22048. Epub 2018 Feb 22. J Biochem Mol Toxicol. 2018. PMID: 29469967
Novel phosphodiesterases inhibitors from the group of purine-2,6-dione derivatives as potent modulators of airway smooth muscle cell remodelling.
Wójcik-Pszczoła K, Chłoń-Rzepa G, Jankowska A, Ellen E, Świerczek A, Pociecha K, Koczurkiewicz P, Piska K, Gawędzka A, Wyska E, Knapik-Czajka M, Pękala E, Gosens R. Wójcik-Pszczoła K, et al. Eur J Pharmacol. 2019 Dec 15;865:172779. doi: 10.1016/j.ejphar.2019.172779. Epub 2019 Nov 6. Eur J Pharmacol. 2019. PMID: 31705904
A Novel, Pan-PDE Inhibitor Exerts Anti-Fibrotic Effects in Human Lung Fibroblasts via Inhibition of TGF-β Signaling and Activation of cAMP/PKA Signaling.
Wójcik-Pszczoła K, Chłoń-Rzepa G, Jankowska A, Ślusarczyk M, Ferdek PE, Kusiak AA, Świerczek A, Pociecha K, Koczurkiewicz-Adamczyk P, Wyska E, Pękala E, Gosens R. Wójcik-Pszczoła K, et al. Int J Mol Sci. 2020 Jun 3;21(11):4008. doi: 10.3390/ijms21114008. Int J Mol Sci. 2020. PMID: 32503342 Free PMC article.
Cinnamic acid derivatives as chemosensitising agents against DOX-treated lung cancer cells - Involvement of carbonyl reductase 1.
Koczurkiewicz-Adamczyk P, Piska K, Gunia-Krzyżak A, Bucki A, Jamrozik M, Lorenc E, Ryszawy D, Wójcik-Pszczoła K, Michalik M, Marona H, Kołaczkowski M, Pękala E. Koczurkiewicz-Adamczyk P, et al. Eur J Pharm Sci. 2020 Nov 1;154:105511. doi: 10.1016/j.ejps.2020.105511. Epub 2020 Aug 13. Eur J Pharm Sci. 2020. PMID: 32801001
Synthesis and in vitro evaluation of anti-inflammatory, antioxidant, and anti-fibrotic effects of new 8-aminopurine-2,6-dione-based phosphodiesterase inhibitors as promising anti-asthmatic agents.
Wójcik-Pszczoła K, Jankowska A, Ślusarczyk M, Jakieła B, Plutecka H, Pociecha K, Świerczek A, Popiół J, Koczurkiewicz-Adamczyk P, Wyska E, Pękala E, Gosens R, Chłoń-Rzepa G. Wójcik-Pszczoła K, et al. Bioorg Chem. 2021 Dec;117:105409. doi: 10.1016/j.bioorg.2021.105409. Epub 2021 Oct 16. Bioorg Chem. 2021. PMID: 34749117 Free article.
In silico and in vitro ADME-Tox analysis and in vivo pharmacokinetic study of representative pan-PDE inhibitors from the group of 7,8-disubstituted derivatives of 1,3-dimethyl-7H-purine-2,6-dione.
Wójcik-Pszczoła K, Szafarz M, Pociecha K, Słoczyńska K, Piska K, Koczurkiewicz-Adamczyk P, Kocot N, Chłoń-Rzepa G, Pękala E, Wyska E. Wójcik-Pszczoła K, et al. Toxicol Appl Pharmacol. 2022 Dec 15;457:116318. doi: 10.1016/j.taap.2022.116318. Epub 2022 Nov 19. Toxicol Appl Pharmacol. 2022. PMID: 36414119
Inhaled pan-phosphodiesterase inhibitors ameliorate ovalbumin-induced airway inflammation and remodeling in murine model of allergic asthma.
Wójcik-Pszczoła K, Pociecha K, Chłoń-Rzepa G, Zadrożna M, Nowak B, Plutecka H, Koczurkiewicz-Adamczyk P, Przejczowska-Pomierny K, Pękala E, Gosens R, Wyska E. Wójcik-Pszczoła K, et al. Int Immunopharmacol. 2023 Jun;119:110264. doi: 10.1016/j.intimp.2023.110264. Epub 2023 May 7. Int Immunopharmacol. 2023. PMID: 37159965 Free article.
35 results