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Phosphoproteomics of patient-derived xenografts identifies targets and markers associated with sensitivity and resistance to EGFR blockade in colorectal cancer.
Sci Transl Med. 2023 Aug 16;15(709):eabm3687. doi: 10.1126/scitranslmed.abm3687. Epub 2023 Aug 16.
Sci Transl Med. 2023.
PMID: 37585503
Free article.
Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell-like phenotype.
Lupo B, Sassi F, Pinnelli M, Galimi F, Zanella ER, Vurchio V, Migliardi G, Gagliardi PA, Puliafito A, Manganaro D, Luraghi P, Kragh M, Pedersen MW, Horak ID, Boccaccio C, Medico E, Primo L, Nichol D, Spiteri I, Heide T, Vatsiou A, Graham TA, Élez E, Argiles G, Nuciforo P, Sottoriva A, Dienstmann R, Pasini D, Grassi E, Isella C, Bertotti A, Trusolino L.
Lupo B, et al. Among authors: vurchio v.
Sci Transl Med. 2020 Aug 5;12(555):eaax8313. doi: 10.1126/scitranslmed.aax8313.
Sci Transl Med. 2020.
PMID: 32759276
Free article.
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INKA, an integrative data analysis pipeline for phosphoproteomic inference of active kinases.
Beekhof R, van Alphen C, Henneman AA, Knol JC, Pham TV, Rolfs F, Labots M, Henneberry E, Le Large TY, de Haas RR, Piersma SR, Vurchio V, Bertotti A, Trusolino L, Verheul HM, Jimenez CR.
Beekhof R, et al. Among authors: vurchio v.
Mol Syst Biol. 2019 Apr 12;15(4):e8250. doi: 10.15252/msb.20188250.
Mol Syst Biol. 2019.
PMID: 30979792
Free PMC article.
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Synthetic Lethal Interaction with BCL-XL Blockade Deepens Response to Cetuximab in Patient-Derived Models of Metastatic Colorectal Cancer.
Leto SM, Ferri M, Sassi F, Zanella ER, Cottino F, Vurchio V, Catalano I, Ferrero A, Zingaretti CC, Marchiò C, Grassi E, Trusolino L, Bertotti A.
Leto SM, et al. Among authors: vurchio v.
Clin Cancer Res. 2023 Mar 14;29(6):1102-1113. doi: 10.1158/1078-0432.CCR-22-2550.
Clin Cancer Res. 2023.
PMID: 36622698
Free PMC article.
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Synthetic Lethality Screening Highlights Colorectal Cancer Vulnerability to Concomitant Blockade of NEDD8 and EGFR Pathways.
Invrea F, Punzi S, Petti C, Minelli R, Peoples MD, Bristow CA, Vurchio V, Corrado A, Bragoni A, Marchiò C, Bertotti A, Trusolino L, Bardelli A, Isella C, Carugo A, Draetta GF, Medico E.
Invrea F, et al. Among authors: vurchio v.
Cancers (Basel). 2021 Jul 28;13(15):3805. doi: 10.3390/cancers13153805.
Cancers (Basel). 2021.
PMID: 34359705
Free PMC article.
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INKA, an integrative data analysis pipeline for phosphoproteomic inference of active kinases.
Beekhof R, van Alphen C, Henneman AA, Knol JC, Pham TV, Rolfs F, Labots M, Henneberry E, Le Large TY, de Haas RR, Piersma SR, Vurchio V, Bertotti A, Trusolino L, Verheul HM, Jimenez CR.
Beekhof R, et al. Among authors: vurchio v.
Mol Syst Biol. 2019 May 24;15(5):e8981. doi: 10.15252/msb.20198981.
Mol Syst Biol. 2019.
PMID: 31126969
Free PMC article.
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Therapeutic efficacy of the bromodomain inhibitor OTX015/MK-8628 in ALK-positive anaplastic large cell lymphoma: an alternative modality to overcome resistant phenotypes.
Boi M, Todaro M, Vurchio V, Yang SN, Moon J, Kwee I, Rinaldi A, Pan H, Crescenzo R, Cheng M, Cerchietti L, Elemento O, Riveiro ME, Cvitkovic E, Bertoni F, Inghirami G; AIRC 5xMille Consortium ‘Genetics-Driven Targeted Management of Lymphoid Malignancies’.
Boi M, et al. Among authors: vurchio v.
Oncotarget. 2016 Nov 29;7(48):79637-79653. doi: 10.18632/oncotarget.12876.
Oncotarget. 2016.
PMID: 27793034
Free PMC article.
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