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A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants.
Pérez-Vargas J, Worrall LJ, Olmstead AD, Ton AT, Lee J, Villanueva I, Thompson CAH, Dudek S, Ennis S, Smith JR, Shapira T, De Guzman J, Gang S, Ban F, Vuckovic M, Bielecki M, Kovacic S, Kenward C, Hong CY, Gordon DG, Levett PN, Krajden M, Leduc R, Boudreault PL, Niikura M, Paetzel M, Young RN, Cherkasov A, Strynadka NCJ, Jean F. Pérez-Vargas J, et al. Among authors: vuckovic m. Emerg Microbes Infect. 2023 Dec;12(2):2246594. doi: 10.1080/22221751.2023.2246594. Emerg Microbes Infect. 2023. PMID: 37555275 Free PMC article.
Structural basis of broad-spectrum β-lactam resistance in Staphylococcus aureus.
Alexander JAN, Worrall LJ, Hu J, Vuckovic M, Satishkumar N, Poon R, Sobhanifar S, Rosell FI, Jenkins J, Chiang D, Mosimann WA, Chambers HF, Paetzel M, Chatterjee SS, Strynadka NCJ. Alexander JAN, et al. Among authors: vuckovic m. Nature. 2023 Jan;613(7943):375-382. doi: 10.1038/s41586-022-05583-3. Epub 2023 Jan 4. Nature. 2023. PMID: 36599987 Free PMC article.
Identification of an Optimized Receptor-Binding Domain Subunit Vaccine against SARS-CoV-2.
Yu H, Worrall LJ, Berger T, Petric M, Lin BH, Vuckovic M, Robb CS, Le Q, Kenward C, Dai C, Wakeham A, Liu S, Snow B, Tobin C, Budylowski P, Guvenc F, You-Ten A, Haight J, Silvester J, Singh RP, Ahn SK, Sultana A, Poon B, Lam J, Christie-Holmes N, Ostrowski M, Gray-Owen SD, Kubli S, Mak T, Strynadka NCJ, Brunham RC. Yu H, et al. Among authors: vuckovic m. J Immunol. 2023 Sep 15;211(6):981-993. doi: 10.4049/jimmunol.2300282. J Immunol. 2023. PMID: 37493438
Structural insight into YcbB-mediated beta-lactam resistance in Escherichia coli.
Caveney NA, Caballero G, Voedts H, Niciforovic A, Worrall LJ, Vuckovic M, Fonvielle M, Hugonnet JE, Arthur M, Strynadka NCJ. Caveney NA, et al. Among authors: vuckovic m. Nat Commun. 2019 Apr 23;10(1):1849. doi: 10.1038/s41467-019-09507-0. Nat Commun. 2019. PMID: 31015395 Free PMC article.
102 results