Vuagniaux G - Search Results

1

SMAC mimetic Debio 1143 synergizes with taxanes, topoisomerase inhibitors and bromodomain inhibitors to impede growth of lung adenocarcinoma cells.

Langdon CG, Wiedemann N, Held MA, Mamillapalli R, Iyidogan P, Theodosakis N, Platt JT, Levy F, Vuagniaux G, Wang S, Bosenberg MW, Stern DF. Langdon CG, et al. Among authors: vuagniaux g. Oncotarget. 2015 Nov 10;6(35):37410-25. doi: 10.18632/oncotarget.6138. Oncotarget. 2015. PMID: 26485762 Free PMC article.

2

SMAC Mimetic Debio 1143 and Ablative Radiation Therapy Synergize to Enhance Antitumor Immunity against Lung Cancer.

Tao Z, McCall NS, Wiedemann N, Vuagniaux G, Yuan Z, Lu B. Tao Z, et al. Among authors: vuagniaux g. Clin Cancer Res. 2019 Feb 1;25(3):1113-1124. doi: 10.1158/1078-0432.CCR-17-3852. Epub 2018 Oct 23. Clin Cancer Res. 2019. PMID: 30352911

3

DEBIO 1143, an IAP inhibitor, reverses carboplatin resistance in ovarian cancer cells and triggers apoptotic or necroptotic cell death.

Thibault B, Genre L, Le Naour A, Broca C, Mery E, Vuagniaux G, Delord JP, Wiedemann N, Couderc B. Thibault B, et al. Among authors: vuagniaux g. Sci Rep. 2018 Dec 14;8(1):17862. doi: 10.1038/s41598-018-35860-z. Sci Rep. 2018. PMID: 30552344 Free PMC article.

4

The radiosensitizing activity of the SMAC-mimetic, Debio 1143, is TNFα-mediated in head and neck squamous cell carcinoma.

Matzinger O, Viertl D, Tsoutsou P, Kadi L, Rigotti S, Zanna C, Wiedemann N, Vozenin MC, Vuagniaux G, Bourhis J. Matzinger O, et al. Among authors: vuagniaux g. Radiother Oncol. 2015 Sep;116(3):495-503. doi: 10.1016/j.radonc.2015.05.017. Epub 2015 Jun 18. Radiother Oncol. 2015. PMID: 26096848

5

The inhibitor apoptosis protein antagonist Debio 1143 Is an attractive HIV-1 latency reversal candidate.

Bobardt M, Kuo J, Chatterji U, Chanda S, Little SJ, Wiedemann N, Vuagniaux G, Gallay PA. Bobardt M, et al. Among authors: vuagniaux g. PLoS One. 2019 Feb 4;14(2):e0211746. doi: 10.1371/journal.pone.0211746. eCollection 2019. PLoS One. 2019. PMID: 30716099 Free PMC article.

6

The inhibitor of apoptosis proteins antagonist Debio 1143 promotes the PD-1 blockade-mediated HIV load reduction in blood and tissues of humanized mice.

Bobardt M, Kuo J, Chatterji U, Wiedemann N, Vuagniaux G, Gallay P. Bobardt M, et al. Among authors: vuagniaux g. PLoS One. 2020 Jan 24;15(1):e0227715. doi: 10.1371/journal.pone.0227715. eCollection 2020. PLoS One. 2020. PMID: 31978106 Free PMC article.

7

Debio 1143, an antagonist of multiple inhibitor-of-apoptosis proteins, activates apoptosis and enhances radiosensitization of non-small cell lung cancer cells in vitro.

Liu N, Tao Z, Blanc JM, Zaorsky NG, Sun Y, Vuagniaux G, Dicker AP, Lu B. Liu N, et al. Among authors: vuagniaux g. Am J Cancer Res. 2014 Nov 19;4(6):943-51. eCollection 2014. Am J Cancer Res. 2014. PMID: 25520882 Free PMC article.

8

Oral Debio1143 (AT406), an antagonist of inhibitor of apoptosis proteins, combined with daunorubicin and cytarabine in patients with poor-risk acute myeloid leukemia--results of a phase I dose-escalation study.

DiPersio JF, Erba HP, Larson RA, Luger SM, Tallman MS, Brill JM, Vuagniaux G, Rouits E, Sorensen JM, Zanna C. DiPersio JF, et al. Among authors: vuagniaux g. Clin Lymphoma Myeloma Leuk. 2015 Jul;15(7):443-9. doi: 10.1016/j.clml.2015.02.020. Epub 2015 Mar 5. Clin Lymphoma Myeloma Leuk. 2015. PMID: 25842225 Free PMC article. Clinical Trial.

9

Exploratory window-of-opportunity trial to investigate the tumor pharmacokinetics/pharmacodynamics of the IAP antagonist Debio 1143 in patients with head and neck cancer.

Gomez-Roca C, Even C, Le Tourneau C, Basté N, Delord JP, Sarini J, Vergez S, Temam S, Hoffmann C, Rochaix P, Borcoman E, Gavillet B, Rouits E, Ménétrey A, Brichory F, Purcea D, Vuagniaux G, Zanna C. Gomez-Roca C, et al. Among authors: vuagniaux g. Clin Transl Sci. 2022 Jan;15(1):55-62. doi: 10.1111/cts.13002. Epub 2021 Nov 11. Clin Transl Sci. 2022. PMID: 33742767 Free PMC article.

10

Phase I Trial of Debio 1143, an Antagonist of Inhibitor of Apoptosis Proteins, Combined with Cisplatin Chemoradiotherapy in Patients with Locally Advanced Squamous Cell Carcinoma of the Head and Neck.

Le Tourneau C, Tao Y, Gomez-Roca C, Cristina V, Borcoman E, Deutsch E, Bahleda R, Calugaru V, Modesto A, Rouits E, Gollmer K, Vuagniaux G, Crompton P, Zanna C, Szyldergemajn S, Delord JP, Bourhis J. Le Tourneau C, et al. Among authors: vuagniaux g. Clin Cancer Res. 2020 Dec 15;26(24):6429-6436. doi: 10.1158/1078-0432.CCR-20-0425. Epub 2020 Sep 29. Clin Cancer Res. 2020. PMID: 32994295 Clinical Trial.

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