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207 results

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Page 1
Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer.
Wasko UN, Jiang J, Dalton TC, Curiel-Garcia A, Edwards AC, Wang Y, Lee B, Orlen M, Tian S, Stalnecker CA, Drizyte-Miller K, Menard M, Dilly J, Sastra SA, Palermo CF, Hasselluhn MC, Decker-Farrell AR, Chang S, Jiang L, Wei X, Yang YC, Helland C, Courtney H, Gindin Y, Muonio K, Zhao R, Kemp SB, Clendenin C, Sor R, Vostrejs WP, Hibshman PS, Amparo AM, Hennessey C, Rees MG, Ronan MM, Roth JA, Brodbeck J, Tomassoni L, Bakir B, Socci ND, Herring LE, Barker NK, Wang J, Cleary JM, Wolpin BM, Chabot JA, Kluger MD, Manji GA, Tsai KY, Sekulic M, Lagana SM, Califano A, Quintana E, Wang Z, Smith JAM, Holderfield M, Wildes D, Lowe SW, Badgley MA, Aguirre AJ, Vonderheide RH, Stanger BZ, Baslan T, Der CJ, Singh M, Olive KP. Wasko UN, et al. Among authors: vonderheide rh. Nature. 2024 Apr 8. doi: 10.1038/s41586-024-07379-z. Online ahead of print. Nature. 2024. PMID: 38588697
Advancing Cancer Interception.
Domchek SM, Vonderheide RH. Domchek SM, et al. Among authors: vonderheide rh. Cancer Discov. 2024 Apr 4;14(4):600-604. doi: 10.1158/2159-8290.CD-24-0015. Cancer Discov. 2024. PMID: 38571414
Machine Learning Links T-cell Function and Spatial Localization to Neoadjuvant Immunotherapy and Clinical Outcome in Pancreatic Cancer.
Blise KE, Sivagnanam S, Betts CB, Betre K, Kirchberger N, Tate BJ, Furth EE, Dias Costa A, Nowak JA, Wolpin BM, Vonderheide RH, Goecks J, Coussens LM, Byrne KT. Blise KE, et al. Among authors: vonderheide rh. Cancer Immunol Res. 2024 May 2;12(5):544-558. doi: 10.1158/2326-6066.CIR-23-0873. Cancer Immunol Res. 2024. PMID: 38381401
Plasticity-induced repression of Irf6 underlies acquired resistance to cancer immunotherapy in pancreatic ductal adenocarcinoma.
Kim IK, Diamond MS, Yuan S, Kemp SB, Kahn BM, Li Q, Lin JH, Li J, Norgard RJ, Thomas SK, Merolle M, Katsuda T, Tobias JW, Baslan T, Politi K, Vonderheide RH, Stanger BZ. Kim IK, et al. Among authors: vonderheide rh. Nat Commun. 2024 Feb 20;15(1):1532. doi: 10.1038/s41467-024-46048-7. Nat Commun. 2024. PMID: 38378697 Free PMC article.
Tumor-selective effects of active RAS inhibition in pancreatic ductal adenocarcinoma.
Wasko UN, Jiang J, Curiel-Garcia A, Wang Y, Lee B, Orlen M, Drizyte-Miller K, Menard M, Dilly J, Sastra SA, Palermo CF, Dalton T, Hasselluhn MC, Decker-Farrell AR, Chang S, Jiang L, Wei X, Yang YC, Helland C, Courtney H, Gindin Y, Zhao R, Kemp SB, Clendenin C, Sor R, Vostrejs W, Amparo AA, Hibshman PS, Rees MG, Ronan MM, Roth JA, Bakir B, Badgley MA, Chabot JA, Kluger MD, Manji GA, Quintana E, Wang Z, Smith JAM, Holderfield M, Wildes D, Aguirre AJ, Der CJ, Vonderheide RH, Stanger BZ, Singh M, Olive KP. Wasko UN, et al. Among authors: vonderheide rh. bioRxiv [Preprint]. 2023 Dec 4:2023.12.03.569791. doi: 10.1101/2023.12.03.569791. bioRxiv. 2023. PMID: 38105998 Free PMC article. Preprint.
Machine learning links T cell function and spatial localization to neoadjuvant immunotherapy and clinical outcome in pancreatic cancer.
Blise KE, Sivagnanam S, Betts CB, Betre K, Kirchberger N, Tate B, Furth EE, Dias Costa A, Nowak JA, Wolpin BM, Vonderheide RH, Goecks J, Coussens LM, Byrne KT. Blise KE, et al. Among authors: vonderheide rh. bioRxiv [Preprint]. 2023 Oct 23:2023.10.20.563335. doi: 10.1101/2023.10.20.563335. bioRxiv. 2023. PMID: 37961410 Free PMC article. Updated. Preprint.
Immune vulnerabilities of mutant KRAS in pancreatic cancer.
Cheng NC, Vonderheide RH. Cheng NC, et al. Among authors: vonderheide rh. Trends Cancer. 2023 Nov;9(11):928-936. doi: 10.1016/j.trecan.2023.07.004. Epub 2023 Jul 29. Trends Cancer. 2023. PMID: 37524642 Review.
Cancer vaccines are back, revitalized.
Vonderheide RH. Vonderheide RH. Med. 2023 Jul 14;4(7):395-397. doi: 10.1016/j.medj.2023.06.004. Med. 2023. PMID: 37453413
Ferroptosis of immune cells in the tumor microenvironment.
Kim R, Taylor D, Vonderheide RH, Gabrilovich DI. Kim R, et al. Among authors: vonderheide rh. Trends Pharmacol Sci. 2023 Aug;44(8):542-552. doi: 10.1016/j.tips.2023.06.005. Epub 2023 Jun 27. Trends Pharmacol Sci. 2023. PMID: 37380530 Review.
Phase I Trial of Autologous RNA-electroporated cMET-directed CAR T Cells Administered Intravenously in Patients with Melanoma and Breast Carcinoma.
Shah PD, Huang AC, Xu X, Orlowski R, Amaravadi RK, Schuchter LM, Zhang P, Tchou J, Matlawski T, Cervini A, Shea J, Gilmore J, Lledo L, Dengel K, Marshall A, Wherry EJ, Linette GP, Brennan A, Gonzalez V, Kulikovskaya I, Lacey SF, Plesa G, June CH, Vonderheide RH, Mitchell TC. Shah PD, et al. Among authors: vonderheide rh. Cancer Res Commun. 2023 May 9;3(5):821-829. doi: 10.1158/2767-9764.CRC-22-0486. eCollection 2023 May. Cancer Res Commun. 2023. PMID: 37377890 Free PMC article. Clinical Trial.
207 results