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Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3.
Prickaerts P, Adriaens ME, Beucken TVD, Koch E, Dubois L, Dahlmans VEH, Gits C, Evelo CTA, Chan-Seng-Yue M, Wouters BG, Voncken JW. Prickaerts P, et al. Among authors: voncken jw. Epigenetics Chromatin. 2016 Oct 26;9:46. doi: 10.1186/s13072-016-0086-0. eCollection 2016. Epigenetics Chromatin. 2016. PMID: 27800026 Free PMC article.
MK3 controls Polycomb target gene expression via negative feedback on ERK.
Prickaerts P, Niessen HE, Mouchel-Vielh E, Dahlmans VE, van den Akker GG, Geijselaers C, Adriaens ME, Spaapen F, Takihara Y, Rapp UR, Peronnet F, Voncken JW. Prickaerts P, et al. Among authors: voncken jw. Epigenetics Chromatin. 2012 Aug 7;5(1):12. doi: 10.1186/1756-8935-5-12. Epigenetics Chromatin. 2012. PMID: 22870894 Free PMC article.
Quantitative analysis of ChIP-seq data uncovers dynamic and sustained H3K4me3 and H3K27me3 modulation in cancer cells under hypoxia.
Adriaens ME, Prickaerts P, Chan-Seng-Yue M, van den Beucken T, Dahlmans VEH, Eijssen LM, Beck T, Wouters BG, Voncken JW, Evelo CTA. Adriaens ME, et al. Among authors: voncken jw. Epigenetics Chromatin. 2016 Nov 1;9:48. doi: 10.1186/s13072-016-0090-4. eCollection 2016. Epigenetics Chromatin. 2016. PMID: 27822313 Free PMC article.
Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER.
van den Beucken T, Koch E, Chu K, Rupaimoole R, Prickaerts P, Adriaens M, Voncken JW, Harris AL, Buffa FM, Haider S, Starmans MHW, Yao CQ, Ivan M, Ivan C, Pecot CV, Boutros PC, Sood AK, Koritzinsky M, Wouters BG. van den Beucken T, et al. Among authors: voncken jw. Nat Commun. 2014 Oct 29;5:5203. doi: 10.1038/ncomms6203. Nat Commun. 2014. PMID: 25351418 Free PMC article.
MK3 modulation affects BMI1-dependent and independent cell cycle check-points.
Prickaerts P, Niessen HE, Dahlmans VE, Spaapen F, Salvaing J, Vanhove J, Geijselaers C, Bartels SJ, Partouns I, Neumann D, Speel EJ, Takihara Y, Wouters BG, Voncken JW. Prickaerts P, et al. Among authors: voncken jw. PLoS One. 2015 Apr 8;10(4):e0118840. doi: 10.1371/journal.pone.0118840. eCollection 2015. PLoS One. 2015. PMID: 25853770 Free PMC article.
The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.
Rouschop KM, van den Beucken T, Dubois L, Niessen H, Bussink J, Savelkouls K, Keulers T, Mujcic H, Landuyt W, Voncken JW, Lambin P, van der Kogel AJ, Koritzinsky M, Wouters BG. Rouschop KM, et al. Among authors: voncken jw. J Clin Invest. 2010 Jan;120(1):127-41. doi: 10.1172/JCI40027. Epub 2009 Dec 14. J Clin Invest. 2010. PMID: 20038797 Free PMC article.
Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control.
Koritzinsky M, Magagnin MG, van den Beucken T, Seigneuric R, Savelkouls K, Dostie J, Pyronnet S, Kaufman RJ, Weppler SA, Voncken JW, Lambin P, Koumenis C, Sonenberg N, Wouters BG. Koritzinsky M, et al. Among authors: voncken jw. EMBO J. 2006 Mar 8;25(5):1114-25. doi: 10.1038/sj.emboj.7600998. Epub 2006 Feb 9. EMBO J. 2006. PMID: 16467844 Free PMC article.
68 results