Von T - Search Results

1

BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation.

Li AG, Murphy EC, Culhane AC, Powell E, Wang H, Bronson RT, Von T, Giobbie-Hurder A, Gelman RS, Briggs KJ, Piwnica-Worms H, Zhao JJ, Kung AL, Kaelin WG Jr, Livingston DM. Li AG, et al. Among authors: von t. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):E9600-E9609. doi: 10.1073/pnas.1807112115. Epub 2018 Sep 25. Proc Natl Acad Sci U S A. 2018. PMID: 30254159 Free PMC article.

2

Functional characterization of an isoform-selective inhibitor of PI3K-p110β as a potential anticancer agent.

Ni J, Liu Q, Xie S, Carlson C, Von T, Vogel K, Riddle S, Benes C, Eck M, Roberts T, Gray N, Zhao J. Ni J, et al. Among authors: von t. Cancer Discov. 2012 May;2(5):425-33. doi: 10.1158/2159-8290.CD-12-0003. Epub 2012 Apr 12. Cancer Discov. 2012. PMID: 22588880 Free PMC article.

3

Spatially distinct roles of class Ia PI3K isoforms in the development and maintenance of PTEN hamartoma tumor syndrome.

Wang Q, Von T, Bronson R, Ruan M, Mu W, Huang A, Maira SM, Zhao JJ. Wang Q, et al. Among authors: von t. Genes Dev. 2013 Jul 15;27(14):1568-80. doi: 10.1101/gad.216069.113. Genes Dev. 2013. PMID: 23873941 Free PMC article.

4

PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context.

Schmit F, Utermark T, Zhang S, Wang Q, Von T, Roberts TM, Zhao JJ. Schmit F, et al. Among authors: von t. Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):6395-400. doi: 10.1073/pnas.1323004111. Epub 2014 Apr 15. Proc Natl Acad Sci U S A. 2014. PMID: 24737887 Free PMC article.

5

MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells.

Wang Y, Lee YM, Baitsch L, Huang A, Xiang Y, Tong H, Lako A, Von T, Choi C, Lim E, Min J, Li L, Stegmeier F, Schlegel R, Eck MJ, Gray NS, Mitchison TJ, Zhao JJ. Wang Y, et al. Among authors: von t. Elife. 2014 May 20;3:e01763. doi: 10.7554/eLife.01763. Elife. 2014. PMID: 24844244 Free PMC article.

6

CDK7-dependent transcriptional addiction in triple-negative breast cancer.

Wang Y, Zhang T, Kwiatkowski N, Abraham BJ, Lee TI, Xie S, Yuzugullu H, Von T, Li H, Lin Z, Stover DG, Lim E, Wang ZC, Iglehart JD, Young RA, Gray NS, Zhao JJ. Wang Y, et al. Among authors: von t. Cell. 2015 Sep 24;163(1):174-86. doi: 10.1016/j.cell.2015.08.063. Cell. 2015. PMID: 26406377 Free PMC article.

7

A PI3K p110β-Rac signalling loop mediates Pten-loss-induced perturbation of haematopoiesis and leukaemogenesis.

Yuzugullu H, Baitsch L, Von T, Steiner A, Tong H, Ni J, Clayton LK, Bronson R, Roberts TM, Gritsman K, Zhao JJ. Yuzugullu H, et al. Among authors: von t. Nat Commun. 2015 Oct 7;6:8501. doi: 10.1038/ncomms9501. Nat Commun. 2015. PMID: 26442967 Free PMC article.

8

PI3K-p110α mediates resistance to HER2-targeted therapy in HER2+, PTEN-deficient breast cancers.

Wang Q, Liu P, Spangle JM, Von T, Roberts TM, Lin NU, Krop IE, Winer EP, Zhao JJ. Wang Q, et al. Among authors: von t. Oncogene. 2016 Jul 7;35(27):3607-12. doi: 10.1038/onc.2015.406. Epub 2015 Oct 26. Oncogene. 2016. PMID: 26500061 Free PMC article.

9

NTRK2 activation cooperates with PTEN deficiency in T-ALL through activation of both the PI3K-AKT and JAK-STAT3 pathways.

Yuzugullu H, Von T, Thorpe LM, Walker SR, Roberts TM, Frank DA, Zhao JJ. Yuzugullu H, et al. Among authors: von t. Cell Discov. 2016 Sep 20;2:16030. doi: 10.1038/celldisc.2016.30. eCollection 2016. Cell Discov. 2016. PMID: 27672444 Free PMC article.

10

PIK3CA C-terminal frameshift mutations are novel oncogenic events that sensitize tumors to PI3K-α inhibition.

Spangle JM, Von T, Pavlick DC, Khotimsky A, Zhao JJ, Roberts TM. Spangle JM, et al. Among authors: von t. Proc Natl Acad Sci U S A. 2020 Sep 29;117(39):24427-24433. doi: 10.1073/pnas.2000060117. Epub 2020 Sep 14. Proc Natl Acad Sci U S A. 2020. PMID: 32929011 Free PMC article.

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