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Discovery and optimization of a broadly-neutralizing human monoclonal antibody against long-chain α-neurotoxins from snakes.
Ledsgaard L, Wade J, Jenkins TP, Boddum K, Oganesyan I, Harrison JA, Villar P, Leah RA, Zenobi R, Schoffelen S, Voldborg B, Ljungars A, McCafferty J, Lomonte B, Gutiérrez JM, Laustsen AH, Karatt-Vellatt A. Ledsgaard L, et al. Among authors: voldborg b. Nat Commun. 2023 Feb 8;14(1):682. doi: 10.1038/s41467-023-36393-4. Nat Commun. 2023. PMID: 36755049 Free PMC article.
Phage display assisted discovery of a pH-dependent anti-α-cobratoxin antibody from a natural variable domain library.
Tulika T, Pedersen RW, Rimbault C, Ahmadi S, Rivera-de-Torre E, Fernández-Quintero ML, Loeffler JR, Bohn MF, Ljungars A, Ledsgaard L, Voldborg BG, Ruso-Julve F, Andersen JT, Laustsen AH. Tulika T, et al. Among authors: voldborg bg. Protein Sci. 2023 Dec;32(12):e4821. doi: 10.1002/pro.4821. Protein Sci. 2023. PMID: 37897425 Free PMC article.
Antibody-dependent enhancement of toxicity of myotoxin II from Bothrops asper.
Sørensen CV, Fernández J, Adams AC, Wildenauer HHK, Schoffelen S, Ledsgaard L, Pucca MB, Fiebig M, Cerni FA, Tulika T, Voldborg BG, Karatt-Vellatt A, Morth JP, Ljungars A, Grav LM, Lomonte B, Laustsen AH. Sørensen CV, et al. Among authors: voldborg bg. Nat Commun. 2024 Jan 16;15(1):173. doi: 10.1038/s41467-023-42624-5. Nat Commun. 2024. PMID: 38228619 Free PMC article.
Glycoengineered recombinant alpha1-antitrypsin results in comparable in vitro and in vivo activities to human plasma-derived protein.
Rocamora F, Schoffelen S, Arnsdorf J, Toth EA, Abdul Y, Cleveland TE 4th, Bjørn SP, Wu MYM, McElvaney NG, Voldborg BGR, Fuerst TR, Lewis NE. Rocamora F, et al. Among authors: voldborg bgr. bioRxiv [Preprint]. 2024 Mar 30:2024.03.27.587088. doi: 10.1101/2024.03.27.587088. bioRxiv. 2024. PMID: 38585818 Free PMC article. Preprint.
Inferring secretory and metabolic pathway activity from omic data with secCellFie.
Masson HO, Samoudi M, Robinson CM, Kuo CC, Weiss L, Shams Ud Doha K, Campos A, Tejwani V, Dahodwala H, Menard P, Voldborg BG, Robasky B, Sharfstein ST, Lewis NE. Masson HO, et al. Among authors: voldborg bg. Metab Eng. 2024 Jan;81:273-285. doi: 10.1016/j.ymben.2023.12.006. Epub 2023 Dec 23. Metab Eng. 2024. PMID: 38145748
Inferring secretory and metabolic pathway activity from omic data with secCellFie.
Masson HO, Samoudi M, Robinson CM, Kuo CC, Weiss L, Doha KSU, Campos A, Tejwani V, Dahodwala H, Menard P, Voldborg BG, Sharfstein ST, Lewis NE. Masson HO, et al. Among authors: voldborg bg. bioRxiv [Preprint]. 2023 May 7:2023.05.04.539316. doi: 10.1101/2023.05.04.539316. bioRxiv. 2023. PMID: 37205389 Free PMC article. Updated. Preprint.
Assessing developability early in the discovery process for novel biologics.
Fernández-Quintero ML, Ljungars A, Waibl F, Greiff V, Andersen JT, Gjølberg TT, Jenkins TP, Voldborg BG, Grav LM, Kumar S, Georges G, Kettenberger H, Liedl KR, Tessier PM, McCafferty J, Laustsen AH. Fernández-Quintero ML, et al. Among authors: voldborg bg. MAbs. 2023 Jan-Dec;15(1):2171248. doi: 10.1080/19420862.2023.2171248. MAbs. 2023. PMID: 36823021 Free PMC article. Review.
35 results