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Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors.
Chafe SC, Vizeacoumar FS, Venkateswaran G, Nemirovsky O, Awrey S, Brown WS, McDonald PC, Carta F, Metcalfe A, Karasinska JM, Huang L, Muthuswamy SK, Schaeffer DF, Renouf DJ, Supuran CT, Vizeacoumar FJ, Dedhar S. Chafe SC, et al. Among authors: vizeacoumar fj, vizeacoumar fs. Sci Adv. 2021 Aug 27;7(35):eabj0364. doi: 10.1126/sciadv.abj0364. Print 2021 Aug. Sci Adv. 2021. PMID: 34452919 Free PMC article.
The genomic and evolutionary landscapes of anaplastic thyroid carcinoma.
Zeng PYF, Prokopec SD, Lai SY, Pinto N, Chan-Seng-Yue MA, Clifton-Bligh R, Williams MD, Howlett CJ, Plantinga P, Cecchini MJ, Lam AK, Siddiqui I, Wang J, Sun RX, Watson JD, Korah R, Carling T, Agrawal N, Cipriani N, Ball D, Nelkin B, Rooper LM, Bishop JA, Garnis C, Berean K, Nicolson NG, Weinberger P, Henderson YC, Lalansingh CM, Tian M, Yamaguchi TN, Livingstone J, Salcedo A, Patel K, Vizeacoumar F, Datti A, Xi L, Nikiforov YE, Smallridge R, Copland JA, Marlow LA, Hyrcza MD, Delbridge L, Sidhu S, Sywak M, Robinson B, Fung K, Ghasemi F, Kwan K, MacNeil SD, Mendez A, Palma DA, Khan MI, Shaikh M, Ruicci KM, Wehrli B, Winquist E, Yoo J, Mymryk JS, Rocco JW, Wheeler D, Scherer S, Giordano TJ, Barrett JW, Faquin WC, Gill AJ, Clayman G, Boutros PC, Nichols AC. Zeng PYF, et al. Cell Rep. 2024 Mar 26;43(3):113826. doi: 10.1016/j.celrep.2024.113826. Epub 2024 Feb 26. Cell Rep. 2024. PMID: 38412093 Free PMC article.
Epigenetic silencing of CREB3L1 by DNA methylation is associated with high-grade metastatic breast cancers with poor prognosis and is prevalent in triple negative breast cancers.
Ward AK, Mellor P, Smith SE, Kendall S, Just NA, Vizeacoumar FS, Sarker S, Phillips Z, Alvi R, Saxena A, Vizeacoumar FJ, Carlsen SA, Anderson DH. Ward AK, et al. Among authors: vizeacoumar fj, vizeacoumar fs. Breast Cancer Res. 2016 Jan 25;18(1):12. doi: 10.1186/s13058-016-0672-x. Breast Cancer Res. 2016. PMID: 26810754 Free PMC article.
Therapeutic relevance of the protein phosphatase 2A in cancer.
Cunningham CE, Li S, Vizeacoumar FS, Bhanumathy KK, Lee JS, Parameswaran S, Furber L, Abuhussein O, Paul JM, McDonald M, Templeton SD, Shukla H, El Zawily AM, Boyd F, Alli N, Mousseau DD, Geyer R, Bonham K, Anderson DH, Yan J, Yu-Lee LY, Weaver BA, Uppalapati M, Ruppin E, Sablina A, Freywald A, Vizeacoumar FJ. Cunningham CE, et al. Among authors: vizeacoumar fj, vizeacoumar fs. Oncotarget. 2016 Sep 20;7(38):61544-61561. doi: 10.18632/oncotarget.11399. Oncotarget. 2016. PMID: 27557495 Free PMC article.
An integrated computational and experimental study uncovers FUT9 as a metabolic driver of colorectal cancer.
Auslander N, Cunningham CE, Toosi BM, McEwen EJ, Yizhak K, Vizeacoumar FS, Parameswaran S, Gonen N, Freywald T, Bhanumathy KK, Freywald A, Vizeacoumar FJ, Ruppin E. Auslander N, et al. Among authors: vizeacoumar fj, vizeacoumar fs. Mol Syst Biol. 2017 Dec 1;13(12):956. doi: 10.15252/msb.20177739. Mol Syst Biol. 2017. PMID: 29196508 Free PMC article.
EPHB6 augments both development and drug sensitivity of triple-negative breast cancer tumours.
Toosi BM, El Zawily A, Truitt L, Shannon M, Allonby O, Babu M, DeCoteau J, Mousseau D, Ali M, Freywald T, Gall A, Vizeacoumar FS, Kirzinger MW, Geyer CR, Anderson DH, Kim T, Welm AL, Siegel P, Vizeacoumar FJ, Kusalik A, Freywald A. Toosi BM, et al. Among authors: vizeacoumar fj, vizeacoumar fs. Oncogene. 2018 Jul;37(30):4073-4093. doi: 10.1038/s41388-018-0228-x. Epub 2018 Apr 27. Oncogene. 2018. PMID: 29700392 Free PMC article.
55 results