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Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target.
Yuthavong Y, Tarnchompoo B, Vilaivan T, Chitnumsub P, Kamchonwongpaisan S, Charman SA, McLennan DN, White KL, Vivas L, Bongard E, Thongphanchang C, Taweechai S, Vanichtanankul J, Rattanajak R, Arwon U, Fantauzzi P, Yuvaniyama J, Charman WN, Matthews D. Yuthavong Y, et al. Among authors: vivas l. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16823-8. doi: 10.1073/pnas.1204556109. Epub 2012 Oct 3. Proc Natl Acad Sci U S A. 2012. PMID: 23035243 Free PMC article.
Anti-malarial activity of N6-modified purine analogues.
Too K, Brown DM, Bongard E, Yardley V, Vivas L, Loakes D. Too K, et al. Among authors: vivas l. Bioorg Med Chem. 2007 Aug 15;15(16):5551-62. doi: 10.1016/j.bmc.2007.05.038. Epub 2007 May 18. Bioorg Med Chem. 2007. PMID: 17548196
In vitro anti-malarial activity of N6-modified purine analogs.
Too K, Brown DM, Loakes D, Bongard E, Vivas L. Too K, et al. Among authors: vivas l. Nucleosides Nucleotides Nucleic Acids. 2007;26(6-7):579-83. doi: 10.1080/15257770701490134. Nucleosides Nucleotides Nucleic Acids. 2007. PMID: 18066859
Malaria diagnosis under field conditions in the Venezuelan Amazon.
Metzger WG, Vivas-Martínez S, Rodriguez I, Gonçalves J, Bongard E, Fanello CI, Vivas L, Magris M. Metzger WG, et al. Among authors: vivas l, vivas martinez s. Trans R Soc Trop Med Hyg. 2008 Jan;102(1):20-4. doi: 10.1016/j.trstmh.2007.08.007. Epub 2007 Oct 4. Trans R Soc Trop Med Hyg. 2008. PMID: 17919672
Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles.
Ellis GL, Amewu R, Sabbani S, Stocks PA, Shone A, Stanford D, Gibbons P, Davies J, Vivas L, Charnaud S, Bongard E, Hall C, Rimmer K, Lozanom S, Jesús M, Gargallo D, Ward SA, O'Neill PM. Ellis GL, et al. Among authors: vivas l. J Med Chem. 2008 Apr 10;51(7):2170-7. doi: 10.1021/jm701435h. Epub 2008 Mar 15. J Med Chem. 2008. PMID: 18341274
Favorable Preclinical Pharmacological Profile of a Novel Antimalarial Pyrrolizidinylmethyl Derivative of 4-amino-7-chloroquinoline with Potent In Vitro and In Vivo Activities.
Basilico N, Parapini S, D'Alessandro S, Misiano P, Romeo S, Dondio G, Yardley V, Vivas L, Nasser S, Rénia L, Russell BM, Suwanarusk R, Nosten F, Sparatore A, Taramelli D. Basilico N, et al. Among authors: vivas l. Biomolecules. 2023 May 14;13(5):836. doi: 10.3390/biom13050836. Biomolecules. 2023. PMID: 37238706 Free PMC article.
Identification and activity of a series of azole-based compounds with lactate dehydrogenase-directed anti-malarial activity.
Cameron A, Read J, Tranter R, Winter VJ, Sessions RB, Brady RL, Vivas L, Easton A, Kendrick H, Croft SL, Barros D, Lavandera JL, Martin JJ, Risco F, García-Ochoa S, Gamo FJ, Sanz L, Leon L, Ruiz JR, Gabarró R, Mallo A, Gómez de las Heras F. Cameron A, et al. Among authors: vivas l. J Biol Chem. 2004 Jul 23;279(30):31429-39. doi: 10.1074/jbc.M402433200. Epub 2004 Apr 26. J Biol Chem. 2004. PMID: 15117937 Free article.
132 results