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7 results
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LRRK2 Inhibition by BIIB122 in Healthy Participants and Patients with Parkinson's Disease.
Mov Disord. 2023 Mar;38(3):386-398. doi: 10.1002/mds.29297. Epub 2023 Feb 18.
Mov Disord. 2023.
PMID: 36807624
Clinical Trial.
The impact of the global COVID-19 pandemic on the conduct of clinical trials: Return to normalcy by considering the practical impact of a structured ethical analysis.
Vissers MFJM, Cohen AF, Van Gerven JMA, Groeneveld GJ.
Vissers MFJM, et al.
Br J Clin Pharmacol. 2021 Mar;87(3):837-844. doi: 10.1111/bcp.14480. Epub 2020 Jul 26.
Br J Clin Pharmacol. 2021.
PMID: 32668047
Free article.
Review.
Item in Clipboard
Targeting for Success: Demonstrating Proof-of-Concept with Mechanistic Early Phase Clinical Pharmacology Studies for Disease-Modification in Neurodegenerative Disorders.
Vissers MFJM, Heuberger JAAC, Groeneveld GJ.
Vissers MFJM, et al.
Int J Mol Sci. 2021 Feb 5;22(4):1615. doi: 10.3390/ijms22041615.
Int J Mol Sci. 2021.
PMID: 33562713
Free PMC article.
Review.
Item in Clipboard
Safety, pharmacokinetics and target engagement of novel RIPK1 inhibitor SAR443060 (DNL747) for neurodegenerative disorders: Randomized, placebo-controlled, double-blind phase I/Ib studies in healthy subjects and patients.
Vissers MFJM, Heuberger JAAC, Groeneveld GJ, Oude Nijhuis J, De Deyn PP, Hadi S, Harris J, Tsai RM, Cruz-Herranz A, Huang F, Tong V, Erickson R, Zhu Y, Scearce-Levie K, Hsiao-Nakamoto J, Tang X, Chang M, Fox BM, Estrada AA, Pomponio RJ, Alonso-Alonso M, Zilberstein M, Atassi N, Troyer MD, Ho C.
Vissers MFJM, et al.
Clin Transl Sci. 2022 Aug;15(8):2010-2023. doi: 10.1111/cts.13317. Epub 2022 Jun 1.
Clin Transl Sci. 2022.
PMID: 35649245
Free PMC article.
Clinical Trial.
Item in Clipboard
A leucine-rich repeat kinase 2 (LRRK2) pathway biomarker characterization study in patients with Parkinson's disease with and without LRRK2 mutations and healthy controls.
Vissers MFJM, Troyer MD, Thijssen E, Pereira DR, Heuberger JAAC, Groeneveld GJ, Huntwork-Rodriguez S.
Vissers MFJM, et al.
Clin Transl Sci. 2023 Aug;16(8):1408-1420. doi: 10.1111/cts.13541. Epub 2023 May 15.
Clin Transl Sci. 2023.
PMID: 37177855
Free PMC article.
Item in Clipboard
Increased Tacrolimus Exposure in Kidney Transplant Recipients With COVID-19: Inflammation-Driven Downregulation of Metabolism as a Potential Mechanism.
Klomp SD, Meziyerh S, Vissers MFJM, Moes DJAR, Arends EJ, Teng YKO, Swen JJ, de Vries APJ.
Klomp SD, et al. Among authors: vissers mfjm.
Transpl Int. 2022 May 16;35:10269. doi: 10.3389/ti.2022.10269. eCollection 2022.
Transpl Int. 2022.
PMID: 35651879
Free PMC article.
Item in Clipboard
Viral clearance, pharmacokinetics and tolerability of ensovibep in patients with mild to moderate COVID-19: A phase 2a, open-label, single-dose escalation study.
Prins MLM, van der Plas JL, Vissers MFJM, Berends CL, Tresch G, Soergel M, Fernández E, van den Berge N, Duijsings D, Zitt C, Stavropoulou V, Zimmermann M, Drake RF, Burggraaf J, Groeneveld GH, Kamerling IMC.
Prins MLM, et al. Among authors: vissers mfjm.
Br J Clin Pharmacol. 2023 Mar;89(3):1105-1114. doi: 10.1111/bcp.15560. Epub 2022 Oct 24.
Br J Clin Pharmacol. 2023.
PMID: 36214216
Free PMC article.
Clinical Trial.
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