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Human diamine oxidase cellular binding and internalization in vitro and rapid clearance in vivo are not mediated by N-glycans but by heparan sulfate proteoglycan interactions.
Gludovacz E, Schuetzenberger K, Resch M, Tillmann K, Petroczi K, Vondra S, Vakal S, Schosserer M, Virgolini N, Pollheimer J, Salminen TA, Jilma B, Borth N, Boehm T. Gludovacz E, et al. Among authors: virgolini n. Glycobiology. 2021 May 3;31(4):444-458. doi: 10.1093/glycob/cwaa090. Glycobiology. 2021. PMID: 32985651
Random epigenetic modulation of CHO cells by repeated knockdown of DNA methyltransferases increases population diversity and enables sorting of cells with higher production capacities.
Weinguny M, Eisenhut P, Klanert G, Virgolini N, Marx N, Jonsson A, Ivansson D, Lövgren A, Borth N. Weinguny M, et al. Among authors: virgolini n. Biotechnol Bioeng. 2020 Nov;117(11):3435-3447. doi: 10.1002/bit.27493. Epub 2020 Jul 24. Biotechnol Bioeng. 2020. PMID: 32662873 Free PMC article.