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Page 1
Sigma-1 receptor modulation fine-tunes KV1.5 channels and impacts pulmonary vascular function.
Vera-Zambrano A, Baena-Nuevo M, Rinné S, Villegas-Esguevillas M, Barreira B, Telli G, de Benito-Bueno A, Blázquez JA, Climent B, Pérez-Vizcaino F, Valenzuela C, Decher N, Gonzalez T, Cogolludo A. Vera-Zambrano A, et al. Among authors: villegas esguevillas m. Pharmacol Res. 2023 Mar;189:106684. doi: 10.1016/j.phrs.2023.106684. Epub 2023 Feb 3. Pharmacol Res. 2023. PMID: 36740150 Free article.
Cigarette smoke induces pulmonary arterial dysfunction through an imbalance in the redox status of the soluble guanylyl cyclase.
Sevilla-Montero J, Munar-Rubert O, Pino-Fadón J, Aguilar-Latorre C, Villegas-Esguevillas M, Climent B, Agrò M, Choya-Foces C, Martínez-Ruiz A, Balsa E, Muñoz-Calleja C, Gómez-Punter RM, Vázquez-Espinosa E, Cogolludo A, Calzada MJ. Sevilla-Montero J, et al. Among authors: villegas esguevillas m. Free Radic Biol Med. 2022 Nov 20;193(Pt 1):9-22. doi: 10.1016/j.freeradbiomed.2022.09.026. Epub 2022 Sep 26. Free Radic Biol Med. 2022. PMID: 36174878 Free article.
Vitamin D Receptor Deficiency Upregulates Pulmonary Artery Kv7 Channel Activity.
Olivencia MA, Villegas-Esguevillas M, Sancho M, Barreira B, Paternoster E, Adão R, Larriba MJ, Cogolludo A, Perez-Vizcaino F. Olivencia MA, et al. Among authors: villegas esguevillas m. Int J Mol Sci. 2023 Aug 2;24(15):12350. doi: 10.3390/ijms241512350. Int J Mol Sci. 2023. PMID: 37569725 Free PMC article.
The novel KV7 channel activator URO-K10 exerts enhanced pulmonary vascular effects independent of the KCNE4 regulatory subunit.
Villegas-Esguevillas M, Cho S, Vera-Zambrano A, Kwon JW, Barreira B, Telli G, Navarro-Dorado J, Morales-Cano D, de Olaiz B, Moreno L, Greenwood I, Pérez-Vizcaíno F, Kim SJ, Climent B, Cogolludo A. Villegas-Esguevillas M, et al. Biomed Pharmacother. 2023 Aug;164:114952. doi: 10.1016/j.biopha.2023.114952. Epub 2023 Jun 7. Biomed Pharmacother. 2023. PMID: 37295249 Free article.
Novel Loss-of-Function KCNA5 Variants in Pulmonary Arterial Hypertension.
Vera-Zambrano A, Lago-Docampo M, Gallego N, Franco-Gonzalez JF, Morales-Cano D, Cruz-Utrilla A, Villegas-Esguevillas M, Fernández-Malavé E, Escribano-Subías P, Tenorio-Castaño JA, Perez-Vizcaino F, Valverde D, González T; Spanish group of Ion Channels in Pulmonary Hypertension (SICPH) investigators; Cogolludo A. Vera-Zambrano A, et al. Among authors: villegas esguevillas m. Am J Respir Cell Mol Biol. 2023 Aug;69(2):147-158. doi: 10.1165/rcmb.2022-0245OC. Am J Respir Cell Mol Biol. 2023. PMID: 36917789