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The complexity of lipoprotein (a) lowering by PCSK9 monoclonal antibodies.
Lambert G, Thedrez A, Croyal M, Ramin-Mangata S, Couret D, Diotel N, Nobécourt-Dupuy E, Krempf M, LeBail JC, Poirier B, Blankenstein J, Villard EF, Guillot E. Lambert G, et al. Among authors: villard ef. Clin Sci (Lond). 2017 Feb 1;131(4):261-268. doi: 10.1042/CS20160403. Clin Sci (Lond). 2017. PMID: 28108631 Review.
PCSK9 Modulates the Secretion But Not the Cellular Uptake of Lipoprotein(a) Ex Vivo: An Effect Blunted by Alirocumab.
Villard EF, Thedrez A, Blankenstein J, Croyal M, Tran TT, Poirier B, Le Bail JC, Illiano S, Nobécourt E, Krempf M, Blom DJ, Marais AD, Janiak P, Muslin AJ, Guillot E, Lambert G. Villard EF, et al. JACC Basic Transl Sci. 2016 Oct;1(6):419-427. doi: 10.1016/j.jacbts.2016.06.006. JACC Basic Transl Sci. 2016. PMID: 29308438 Free PMC article.
PCSK9 inhibition with alirocumab reduces lipoprotein(a) levels in nonhuman primates by lowering apolipoprotein(a) production rate.
Croyal M, Tran TT, Blanchard RH, Le Bail JC, Villard EF, Poirier B, Aguesse A, Billon-Crossouard S, Ramin-Mangata S, Blanchard V, Nativel B, Chemello K, Khantalin I, Thedrez A, Janiak P, Krempf M, Boixel C, Lambert G, Guillot E. Croyal M, et al. Among authors: villard ef. Clin Sci (Lond). 2018 May 31;132(10):1075-1083. doi: 10.1042/CS20180040. Print 2018 May 31. Clin Sci (Lond). 2018. PMID: 29724769
Lipoprotein(a) Cellular Uptake Ex Vivo and Hepatic Capture In Vivo Is Insensitive to PCSK9 Inhibition With Alirocumab.
Chemello K, Beeské S, Trang Tran TT, Blanchard V, Villard EF, Poirier B, Le Bail JC, Dargazanli G, Ho-Van-Guimbal S, Boulay D, Bergis O, Pruniaux MP, Croyal M, Janiak P, Guillot E, Lambert G. Chemello K, et al. Among authors: villard ef. JACC Basic Transl Sci. 2020 May 6;5(6):549-557. doi: 10.1016/j.jacbts.2020.03.008. eCollection 2020 Jun. JACC Basic Transl Sci. 2020. PMID: 32613143 Free PMC article.
High Glucose Activates YAP Signaling to Promote Vascular Inflammation.
Ortillon J, Le Bail JC, Villard E, Léger B, Poirier B, Girardot C, Beeske S, Ledein L, Blanchard V, Brieu P, Naimi S, Janiak P, Guillot E, Meloni M. Ortillon J, et al. Front Physiol. 2021 Jun 4;12:665994. doi: 10.3389/fphys.2021.665994. eCollection 2021. Front Physiol. 2021. PMID: 34149446 Free PMC article.
Human ATP-binding cassette G1 controls macrophage lipoprotein lipase bioavailability and promotes foam cell formation.
Olivier M, Tanck MW, Out R, Villard EF, Lammers B, Bouchareychas L, Frisdal E, Superville A, Van Berkel T, Kastelein JJ, Eck MV, Jukema JW, Chapman MJ, Dallinga-Thie GM, Guerin M, Le Goff W. Olivier M, et al. Among authors: villard ef. Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):2223-31. doi: 10.1161/ATVBAHA.111.243519. Epub 2012 Jul 5. Arterioscler Thromb Vasc Biol. 2012. PMID: 22772754
17 results