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The γ-Benzylidene Digoxin Derivative BD-15 Increases the α3-Na, K-ATPase Activity in Rat Hippocampus and Prefrontal Cortex and no Change on Heart.
Parreira GM, Faria JA, Marques SMS, Garcia IJP, Silva IF, De Carvalho LED, Villar JAFP, Machado MV, de Castro Lima M, Barbosa LA, Cortes VF, de Lima Santos H. Parreira GM, et al. Among authors: villar jafp. J Membr Biol. 2021 Apr;254(2):189-199. doi: 10.1007/s00232-021-00173-2. Epub 2021 Feb 18. J Membr Biol. 2021. PMID: 33598793
21‑Benzylidene digoxin, a novel digoxin hemi-synthetic derivative, presents an anti-inflammatory activity through inhibition of edema, tumour necrosis factor alpha production, inducible nitric oxide synthase expression and leucocyte migration.
Vieira L, Saldanha AA, Moraes AM, Oliveira FM, Lopes DO, Barbosa LAO, Ribeiro RIMA, Thomé RG, Santos HBD, Villar JAFP, Soares AC. Vieira L, et al. Among authors: villar jafp. Int Immunopharmacol. 2018 Dec;65:174-181. doi: 10.1016/j.intimp.2018.10.010. Epub 2018 Oct 10. Int Immunopharmacol. 2018. PMID: 30316075 Free article.
Evaluation of Cardiotonic Steroid Modulation of Cellular Cholesterol and Phospholipid.
Silva LND, Garcia IJP, Valadares JMM, Pessoa MTC, Toledo MM, Machado MV, Busch MS, Rocha I, Villar JAFP, Atella GC, Santos HL, Cortes VF, Barbosa LA. Silva LND, et al. Among authors: villar jafp. J Membr Biol. 2021 Dec;254(5-6):499-512. doi: 10.1007/s00232-021-00203-z. Epub 2021 Oct 29. J Membr Biol. 2021. PMID: 34716469
21-Benzylidene digoxin decreases proliferation by inhibiting the EGFR/ERK signaling pathway and induces apoptosis in HeLa cells.
Pessôa MTC, Valadares JMM, Rocha SC, Silva SC, McDermott JP, Sánchez G, Varotti FP, Scavone C, Ribeiro RIMA, Villar JAFP, Blanco G, Barbosa LA. Pessôa MTC, et al. Among authors: villar jafp. Steroids. 2020 Mar;155:108551. doi: 10.1016/j.steroids.2019.108551. Epub 2019 Dec 6. Steroids. 2020. PMID: 31812624 Free PMC article.
23 results