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SRC family kinase (SFK) inhibitor dasatinib improves the antitumor activity of anti-PD-1 in NSCLC models by inhibiting Treg cell conversion and proliferation.
Redin E, Garmendia I, Lozano T, Serrano D, Senent Y, Redrado M, Villalba M, De Andrea CE, Exposito F, Ajona D, Ortiz-Espinosa S, Remirez A, Bertolo C, Sainz C, Garcia-Pedrero J, Pio R, Lasarte J, Agorreta J, Montuenga LM, Calvo A. Redin E, et al. Among authors: villalba m. J Immunother Cancer. 2021 Mar;9(3):e001496. doi: 10.1136/jitc-2020-001496. J Immunother Cancer. 2021. PMID: 33658304 Free PMC article.
Development of biological tools to assess the role of TMPRSS4 and identification of novel tumor types with high expression of this prometastatic protein.
Villalba M, Lopez L, Redrado M, Ruiz T, de Aberasturi AL, de la Roja N, Garcia D, Exposito F, de Andrea C, Alvarez-Fernandez E, Montuenga L, Rueda P, Rodriguez MJ, Calvo A. Villalba M, et al. Histol Histopathol. 2017 Sep;32(9):929-940. doi: 10.14670/HH-11-857. Epub 2016 Dec 20. Histol Histopathol. 2017. PMID: 27995596
miR-146a targets c-met and abolishes colorectal cancer liver metastasis.
Bleau AM, Redrado M, Nistal-Villan E, Villalba M, Exposito F, Redin E, de Aberasturi AL, Larzabal L, Freire J, Gomez-Roman J, Calvo A. Bleau AM, et al. Among authors: villalba m. Cancer Lett. 2018 Feb 1;414:257-267. doi: 10.1016/j.canlet.2017.11.008. Epub 2017 Nov 11. Cancer Lett. 2018. PMID: 29133238
Identification of a novel synthetic lethal vulnerability in non-small cell lung cancer by co-targeting TMPRSS4 and DDR1.
Villalba M, Redin E, Exposito F, Pajares MJ, Sainz C, Hervas D, Guruceaga E, Diaz-Lagares A, Cirauqui C, Redrado M, Valencia K, de Andrea C, Jantus-Lewintre E, Camps C, Lopez-Lopez R, Lahoz A, Montuenga L, Pio R, Sandoval J, Calvo A. Villalba M, et al. Sci Rep. 2019 Oct 28;9(1):15400. doi: 10.1038/s41598-019-51066-3. Sci Rep. 2019. PMID: 31659178 Free PMC article.
Intratumoral co-injection of the poly I:C-derivative BO-112 and a STING agonist synergize to achieve local and distant anti-tumor efficacy.
Alvarez M, Molina C, De Andrea CE, Fernandez-Sendin M, Villalba M, Gonzalez-Gomariz J, Ochoa MC, Teijeira A, Glez-Vaz J, Aranda F, Sanmamed MF, Rodriguez-Ruiz ME, Fan X, Shen WH, Berraondo P, Quintero M, Melero I. Alvarez M, et al. Among authors: villalba m. J Immunother Cancer. 2021 Nov;9(11):e002953. doi: 10.1136/jitc-2021-002953. J Immunother Cancer. 2021. PMID: 34824158 Free PMC article.
Epigenetic alterations leading to TMPRSS4 promoter hypomethylation and protein overexpression predict poor prognosis in squamous lung cancer patients.
Villalba M, Diaz-Lagares A, Redrado M, de Aberasturi AL, Segura V, Bodegas ME, Pajares MJ, Pio R, Freire J, Gomez-Roman J, Montuenga LM, Esteller M, Sandoval J, Calvo A. Villalba M, et al. Oncotarget. 2016 Apr 19;7(16):22752-69. doi: 10.18632/oncotarget.8045. Oncotarget. 2016. PMID: 26989022 Free PMC article.
497 results