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Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice.
Aoun M, Coelho A, Krämer A, Saxena A, Sabatier P, Beusch CM, Lönnblom E, Geng M, Do NN, Xu Z, Zhang J, He Y, Romero Castillo L, Abolhassani H, Xu B, Viljanen J, Rorbach J, Fernandez Lahore G, Gjertsson I, Kastbom A, Sjöwall C, Kihlberg J, Zubarev RA, Burkhardt H, Holmdahl R. Aoun M, et al. Among authors: viljanen j. J Exp Med. 2023 Nov 6;220(11):e20230101. doi: 10.1084/jem.20230101. Epub 2023 Sep 11. J Exp Med. 2023. PMID: 37695523 Free PMC article.
Therapy targeting antigen-specific T cells by a peptide-based tolerizing vaccine against autoimmune arthritis.
Urbonaviciute V, Romero-Castillo L, Xu B, Luo H, Schneider N, Weisse S, Do NN, Oliveira-Coelho A, Fernandez Lahore G, Li T, Sabatier P, Beusch CM, Viljanen J, Zubarev RA, Kihlberg J, Bäcklund J, Burkhardt H, Holmdahl R. Urbonaviciute V, et al. Among authors: viljanen j. Proc Natl Acad Sci U S A. 2023 Jun 20;120(25):e2218668120. doi: 10.1073/pnas.2218668120. Epub 2023 Jun 12. Proc Natl Acad Sci U S A. 2023. PMID: 37307481 Free PMC article.
A Shared Epitope of Collagen Type XI and Type II Is Recognized by Pathogenic Antibodies in Mice and Humans with Arthritis.
Tong D, Lönnblom E, Yau ACY, Nandakumar KS, Liang B, Ge C, Viljanen J, Li L, Bãlan M, Klareskog L, Chagin AS, Gjertsson I, Kihlberg J, Zhao M, Holmdahl R. Tong D, et al. Among authors: viljanen j. Front Immunol. 2018 Apr 12;9:451. doi: 10.3389/fimmu.2018.00451. eCollection 2018. Front Immunol. 2018. PMID: 29706949 Free PMC article.
Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor.
Ge C, Weisse S, Xu B, Dobritzsch D, Viljanen J, Kihlberg J, Do NN, Schneider N, Lanig H, Holmdahl R, Burkhardt H. Ge C, et al. Among authors: viljanen j. Ann Rheum Dis. 2022 Apr;81(4):480-489. doi: 10.1136/annrheumdis-2021-220500. Epub 2022 Jan 13. Ann Rheum Dis. 2022. PMID: 35027402 Free PMC article.
Autoantibodies to Disease-Related Proteins in Joints as Novel Biomarkers for the Diagnosis of Rheumatoid Arthritis.
Lönnblom E, Leu Agelii M, Sareila O, Cheng L, Xu B, Viljanen J, Hafström I, Andersson MLE, Bergström G, Hultgård Ekwall AK, Rudin A, Kastbom A, Sjöwall C, Jacobsson LTH, Kihlberg J, Gjertsson I, Holmdahl R. Lönnblom E, et al. Among authors: viljanen j. Arthritis Rheumatol. 2023 Jul;75(7):1110-1119. doi: 10.1002/art.42463. Epub 2023 Apr 27. Arthritis Rheumatol. 2023. PMID: 36718635 Free article.
Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage.
Ge C, Tong D, Liang B, Lönnblom E, Schneider N, Hagert C, Viljanen J, Ayoglu B, Stawikowska R, Nilsson P, Fields GB, Skogh T, Kastbom A, Kihlberg J, Burkhardt H, Dobritzsch D, Holmdahl R. Ge C, et al. Among authors: viljanen j. JCI Insight. 2017 Jul 6;2(13):e93688. doi: 10.1172/jci.insight.93688. eCollection 2017 Jul 6. JCI Insight. 2017. PMID: 28679953 Free PMC article.
40 results