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Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer's Disease.
Le Douce J, Maugard M, Veran J, Matos M, Jégo P, Vigneron PA, Faivre E, Toussay X, Vandenberghe M, Balbastre Y, Piquet J, Guiot E, Tran NT, Taverna M, Marinesco S, Koyanagi A, Furuya S, Gaudin-Guérif M, Goutal S, Ghettas A, Pruvost A, Bemelmans AP, Gaillard MC, Cambon K, Stimmer L, Sazdovitch V, Duyckaerts C, Knott G, Hérard AS, Delzescaux T, Hantraye P, Brouillet E, Cauli B, Oliet SHR, Panatier A, Bonvento G. Le Douce J, et al. Among authors: vigneron pa. Cell Metab. 2020 Mar 3;31(3):503-517.e8. doi: 10.1016/j.cmet.2020.02.004. Cell Metab. 2020. PMID: 32130882 Free article.
l-Serine links metabolism with neurotransmission.
Maugard M, Vigneron PA, Bolaños JP, Bonvento G. Maugard M, et al. Among authors: vigneron pa. Prog Neurobiol. 2021 Feb;197:101896. doi: 10.1016/j.pneurobio.2020.101896. Epub 2020 Aug 14. Prog Neurobiol. 2021. PMID: 32798642 Review.
Evidence supporting a role for astrocytes in the regulation of cognitive flexibility and neuronal oscillations through the Ca2+ binding protein S100β.
Brockett AT, Kane GA, Monari PK, Briones BA, Vigneron PA, Barber GA, Bermudez A, Dieffenbach U, Kloth AD, Buschman TJ, Gould E. Brockett AT, et al. Among authors: vigneron pa. PLoS One. 2018 Apr 17;13(4):e0195726. doi: 10.1371/journal.pone.0195726. eCollection 2018. PLoS One. 2018. PMID: 29664924 Free PMC article.