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Perspective on computational and structural aspects of kinase discovery from IPK2014.
Martin E, Knapp S, Engh RA, Moebitz H, Varin T, Roux B, Meiler J, Berdini V, Baumann A, Vieth M. Martin E, et al. Among authors: vieth m. Biochim Biophys Acta. 2015 Oct;1854(10 Pt B):1595-604. doi: 10.1016/j.bbapap.2015.03.014. Epub 2015 Apr 7. Biochim Biophys Acta. 2015. PMID: 25861861 Free PMC article. Review.
Discovery of selective RIO2 kinase small molecule ligand.
Varin T, Godfrey AG, Masquelin T, Nicolaou CA, Evans DA, Vieth M. Varin T, et al. Among authors: vieth m. Biochim Biophys Acta. 2015 Oct;1854(10 Pt B):1630-6. doi: 10.1016/j.bbapap.2015.04.006. Epub 2015 Apr 17. Biochim Biophys Acta. 2015. PMID: 25891899
The discovery of a new structural class of cyclin-dependent kinase inhibitors, aminoimidazo[1,2-a]pyridines.
Hamdouchi C, Keyser H, Collins E, Jaramillo C, De Diego JE, Spencer CD, Dempsey JA, Anderson BD, Leggett T, Stamm NB, Schultz RM, Watkins SA, Cocke K, Lemke S, Burke TF, Beckmann RP, Dixon JT, Gurganus TM, Rankl NB, Houck KA, Zhang F, Vieth M, Espinosa J, Timm DE, Campbell RM, Patel BK, Brooks HB. Hamdouchi C, et al. Among authors: vieth m. Mol Cancer Ther. 2004 Jan;3(1):1-9. Mol Cancer Ther. 2004. PMID: 14749470
675 results