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FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation.
Birsa N, Ule AM, Garone MG, Tsang B, Mattedi F, Chong PA, Humphrey J, Jarvis S, Pisiren M, Wilkins OG, Nosella ML, Devoy A, Bodo C, de la Fuente RF, Fisher EMC, Rosa A, Viero G, Forman-Kay JD, Schiavo G, Fratta P. Birsa N, et al. Among authors: viero g. Sci Adv. 2021 Jul 21;7(30):eabf8660. doi: 10.1126/sciadv.abf8660. Print 2021 Jul. Sci Adv. 2021. PMID: 34290090 Free PMC article.
C9orf72 ALS/FTD dipeptide repeat protein levels are reduced by small molecules that inhibit PKA or enhance protein degradation.
Licata NV, Cristofani R, Salomonsson S, Wilson KM, Kempthorne L, Vaizoglu D, D'Agostino VG, Pollini D, Loffredo R, Pancher M, Adami V, Bellosta P, Ratti A, Viero G, Quattrone A, Isaacs AM, Poletti A, Provenzani A. Licata NV, et al. Among authors: viero g. EMBO J. 2022 Jan 4;41(1):e105026. doi: 10.15252/embj.2020105026. Epub 2021 Nov 18. EMBO J. 2022. PMID: 34791698 Free PMC article.
Hydrogen peroxide induced by nerve injury promotes axon regeneration via connective tissue growth factor.
Negro S, Lauria F, Stazi M, Tebaldi T, D'Este G, Pirazzini M, Megighian A, Lessi F, Mazzanti CM, Sales G, Romualdi C, Fillo S, Lista F, Sleigh JN, Tosolini AP, Schiavo G, Viero G, Rigoni M. Negro S, et al. Among authors: viero g. Acta Neuropathol Commun. 2022 Dec 25;10(1):189. doi: 10.1186/s40478-022-01495-5. Acta Neuropathol Commun. 2022. PMID: 36567321 Free PMC article.
mRNA fate: Life and death of the mRNA in the cytoplasm.
Denti MA, Viero G, Provenzani A, Quattrone A, Macchi P. Denti MA, et al. Among authors: viero g. RNA Biol. 2013 Mar;10(3):360-6. doi: 10.4161/rna.23770. Epub 2013 Mar 1. RNA Biol. 2013. PMID: 23466755 Free PMC article.
Neuronal models of TDP-43 proteinopathy display reduced axonal translation, increased oxidative stress, and defective exocytosis.
Pisciottani A, Croci L, Lauria F, Marullo C, Savino E, Ambrosi A, Podini P, Marchioretto M, Casoni F, Cremona O, Taverna S, Quattrini A, Cioni JM, Viero G, Codazzi F, Consalez GG. Pisciottani A, et al. Among authors: viero g. Front Cell Neurosci. 2023 Nov 13;17:1253543. doi: 10.3389/fncel.2023.1253543. eCollection 2023. Front Cell Neurosci. 2023. PMID: 38026702 Free PMC article.
75 results