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The impact of inosine on hippocampal synaptic transmission and plasticity involves the release of adenosine through equilibrative nucleoside transporters rather than the direct activation of adenosine receptors.
Valada P, Hinz S, Vielmuth C, Lopes CR, Cunha RA, Müller CE, Lopes JP. Valada P, et al. Among authors: vielmuth c. Purinergic Signal. 2023 Jun;19(2):451-461. doi: 10.1007/s11302-022-09899-7. Epub 2022 Sep 26. Purinergic Signal. 2023. PMID: 36156760 Free PMC article.
Synthesis of novel pyrido[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives: potent and selective adenosine A3 receptor antagonists.
Banda V, Chandrasekaran B, Köse M, Vielmuth C, Müller CE, Chavva K, Gautham SK, Pillalamarri S, Mylavaram R, Akkinepally R, Pamulaparthy S, Banda N. Banda V, et al. Among authors: vielmuth c. Arch Pharm (Weinheim). 2013 Oct;346(10):699-707. doi: 10.1002/ardp.201300003. Epub 2013 Aug 30. Arch Pharm (Weinheim). 2013. PMID: 23996524
8-Benzylaminoxanthine scaffold variations for selective ligands acting on adenosine A2A receptors. Design, synthesis and biological evaluation.
Załuski M, Schabikowski J, Jaśko P, Bryła A, Olejarz-Maciej A, Kaleta M, Głuch-Lutwin M, Brockmann A, Hinz S, Zygmunt M, Kuder K, Latacz G, Vielmuth C, Müller CE, Kieć-Kononowicz K. Załuski M, et al. Among authors: vielmuth c. Bioorg Chem. 2020 Aug;101:104033. doi: 10.1016/j.bioorg.2020.104033. Epub 2020 Jun 19. Bioorg Chem. 2020. PMID: 32629282
Targeting the Main Protease of SARS-CoV-2: From the Establishment of High Throughput Screening to the Design of Tailored Inhibitors.
Breidenbach J, Lemke C, Pillaiyar T, Schäkel L, Al Hamwi G, Diett M, Gedschold R, Geiger N, Lopez V, Mirza S, Namasivayam V, Schiedel AC, Sylvester K, Thimm D, Vielmuth C, Phuong Vu L, Zyulina M, Bodem J, Gütschow M, Müller CE. Breidenbach J, et al. Among authors: vielmuth c. Angew Chem Int Ed Engl. 2021 Apr 26;60(18):10423-10429. doi: 10.1002/anie.202016961. Epub 2021 Mar 24. Angew Chem Int Ed Engl. 2021. PMID: 33655614 Free PMC article.
Single Stabilizing Point Mutation Enables High-Resolution Co-Crystal Structures of the Adenosine A2A Receptor with Preladenant Conjugates.
Claff T, Klapschinski TA, Tiruttani Subhramanyam UK, Vaaßen VJ, Schlegel JG, Vielmuth C, Voß JH, Labahn J, Müller CE. Claff T, et al. Among authors: vielmuth c. Angew Chem Int Ed Engl. 2022 May 23;61(22):e202115545. doi: 10.1002/anie.202115545. Epub 2022 Mar 24. Angew Chem Int Ed Engl. 2022. PMID: 35174942 Free PMC article.
Irreversible Antagonists for the Adenosine A2B Receptor.
Temirak A, Schlegel JG, Voss JH, Vaaßen VJ, Vielmuth C, Claff T, Müller CE. Temirak A, et al. Among authors: vielmuth c. Molecules. 2022 Jun 13;27(12):3792. doi: 10.3390/molecules27123792. Molecules. 2022. PMID: 35744918 Free PMC article.
Anti-Inflammatory Activities of 8-Benzylaminoxanthines Showing High Adenosine A2A and Dual A1/A2A Receptor Affinity.
Załuski M, Łażewska D, Jaśko P, Honkisz-Orzechowska E, Kuder KJ, Brockmann A, Latacz G, Zygmunt M, Kaleta M, Greser BA, Olejarz-Maciej A, Jastrzębska-Więsek M, Vielmuth C, Müller CE, Kieć-Kononowicz K. Załuski M, et al. Among authors: vielmuth c. Int J Mol Sci. 2023 Sep 5;24(18):13707. doi: 10.3390/ijms241813707. Int J Mol Sci. 2023. PMID: 37762006 Free PMC article.