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Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths.
Bastard P, Gervais A, Le Voyer T, Rosain J, Philippot Q, Manry J, Michailidis E, Hoffmann HH, Eto S, Garcia-Prat M, Bizien L, Parra-Martínez A, Yang R, Haljasmägi L, Migaud M, Särekannu K, Maslovskaja J, de Prost N, Tandjaoui-Lambiotte Y, Luyt CE, Amador-Borrero B, Gaudet A, Poissy J, Morel P, Richard P, Cognasse F, Troya J, Trouillet-Assant S, Belot A, Saker K, Garçon P, Rivière JG, Lagier JC, Gentile S, Rosen LB, Shaw E, Morio T, Tanaka J, Dalmau D, Tharaux PL, Sene D, Stepanian A, Megarbane B, Triantafyllia V, Fekkar A, Heath JR, Franco JL, Anaya JM, Solé-Violán J, Imberti L, Biondi A, Bonfanti P, Castagnoli R, Delmonte OM, Zhang Y, Snow AL, Holland SM, Biggs C, Moncada-Vélez M, Arias AA, Lorenzo L, Boucherit S, Coulibaly B, Anglicheau D, Planas AM, Haerynck F, Duvlis S, Nussbaum RL, Ozcelik T, Keles S, Bousfiha AA, El Bakkouri J, Ramirez-Santana C, Paul S, Pan-Hammarström Q, Hammarström L, Dupont A, Kurolap A, Metz CN, Aiuti A, Casari G, Lampasona V, Ciceri F, Barreiros LA, Dominguez-Garrido E, Vidigal M, Zatz M, van de Beek D, Sahanic S, Tancevski I, Stepanovskyy Y, Boyarchuk O, Nukui Y, Tsumura M, Vidaur L, Tangye SG, Burrel S, Duffy D, Quintana-Murci L, Klocperk A, K… See abstract for full author list ➔ Bastard P, et al. Among authors: vidaur l. Sci Immunol. 2021 Aug 19;6(62):eabl4340. doi: 10.1126/sciimmunol.abl4340. Sci Immunol. 2021. PMID: 34413139 Free PMC article.
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies.
Manry J, Bastard P, Gervais A, Le Voyer T, Rosain J, Philippot Q, Michailidis E, Hoffmann HH, Eto S, Garcia-Prat M, Bizien L, Parra-Martínez A, Yang R, Haljasmägi L, Migaud M, Särekannu K, Maslovskaja J, de Prost N, Tandjaoui-Lambiotte Y, Luyt CE, Amador-Borrero B, Gaudet A, Poissy J, Morel P, Richard P, Cognasse F, Troya J, Trouillet-Assant S, Belot A, Saker K, Garçon P, Rivière JG, Lagier JC, Gentile S, Rosen LB, Shaw E, Morio T, Tanaka J, Dalmau D, Tharaux PL, Sene D, Stepanian A, Mégarbane B, Triantafyllia V, Fekkar A, Heath JR, Franco JL, Anaya JM, Solé-Violán J, Imberti L, Biondi A, Bonfanti P, Castagnoli R, Delmonte OM, Zhang Y, Snow AL, Holland SM, Biggs CM, Moncada-Vélez M, Arias AA, Lorenzo L, Boucherit S, Anglicheau D, Planas AM, Haerynck F, Duvlis S, Ozcelik T, Keles S, Bousfiha AA, El Bakkouri J, Ramirez-Santana C, Paul S, Pan-Hammarström Q, Hammarström L, Dupont A, Kurolap A, Metz CN, Aiuti A, Casari G, Lampasona V, Ciceri F, Barreiros LA, Dominguez-Garrido E, Vidigal M, Zatz M, van de Beek D, Sahanic S, Tancevski I, Stepanovskyy Y, Boyarchuk O, Nukui Y, Tsumura M, Vidaur L, Tangye SG, Burrel S, Duffy D, Quintana-Murci L, Klocperk A, Kann NY, Shcherbina A, Lau… See abstract for full author list ➔ Manry J, et al. Among authors: vidaur l. Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2200413119. doi: 10.1073/pnas.2200413119. Epub 2022 May 16. Proc Natl Acad Sci U S A. 2022. PMID: 35576468 Free PMC article.
Effectiveness of prolonged versus standard-course of oseltamivir in critically ill patients with severe influenza infection: A multicentre cohort study.
Moreno G, Carbonell R, Díaz E, Martín-Loeches I, Restrepo MI, Reyes LF, Solé-Violán J, Bodí M, Canadell L, Guardiola J, Trefler S, Vidaur L, Papiol E, Socias L, Correig E, Marín-Corral J, Rodríguez A; GETGAG Working Group. Moreno G, et al. Among authors: vidaur l. J Med Virol. 2023 Aug;95(8):e29010. doi: 10.1002/jmv.29010. J Med Virol. 2023. PMID: 37537755
Procalcitonin (PCT) levels for ruling-out bacterial coinfection in ICU patients with influenza: A CHAID decision-tree analysis.
Rodríguez AH, Avilés-Jurado FX, Díaz E, Schuetz P, Trefler SI, Solé-Violán J, Cordero L, Vidaur L, Estella Á, Pozo Laderas JC, Socias L, Vergara JC, Zaragoza R, Bonastre J, Guerrero JE, Suberviola B, Cilloniz C, Restrepo MI, Martín-Loeches I; SEMICYUC/GETGAG Working Group. Rodríguez AH, et al. Among authors: vidaur l. J Infect. 2016 Feb;72(2):143-51. doi: 10.1016/j.jinf.2015.11.007. Epub 2015 Dec 15. J Infect. 2016. PMID: 26702737 Free article.
Early oseltamivir treatment improves survival in critically ill patients with influenza pneumonia.
Moreno G, Rodríguez A, Sole-Violán J, Martín-Loeches I, Díaz E, Bodí M, Reyes LF, Gómez J, Guardiola J, Trefler S, Vidaur L, Papiol E, Socias L, García-Vidal C, Correig E, Marín-Corral J, Restrepo MI, Nguyen-Van-Tam JS, Torres A. Moreno G, et al. Among authors: vidaur l. ERJ Open Res. 2021 Mar 8;7(1):00888-2020. doi: 10.1183/23120541.00888-2020. eCollection 2021 Jan. ERJ Open Res. 2021. PMID: 33718494 Free PMC article.
Community-acquired Legionella Pneumonia in the intensive care unit: Impact on survival of combined antibiotic therapy.
Rello J, Gattarello S, Souto J, Sole-Violan J, Valles J, Peredo R, Zaragoza R, Vidaur L, Parra A, Roig J; Community-Acquired Pneumonia in Unidad de Cuidados Intensivos 2 CAPUCI 2 Study Investigators. Rello J, et al. Among authors: vidaur l. Med Intensiva. 2013 Jun-Jul;37(5):320-6. doi: 10.1016/j.medin.2012.05.010. Epub 2012 Jul 31. Med Intensiva. 2013. PMID: 22854618 Free article.
Factors associated with ventilator-associated events: an international multicenter prospective cohort study.
Rello J, Ramírez-Estrada S, Romero A, Arvaniti K, Koulenti D, Nseir S, Oztoprak N, Bouadma L, Vidaur L, Lagunes L, Peña-López Y; EUVAE Study Group. Rello J, et al. Among authors: vidaur l. Eur J Clin Microbiol Infect Dis. 2019 Sep;38(9):1693-1699. doi: 10.1007/s10096-019-03596-x. Epub 2019 Jun 24. Eur J Clin Microbiol Infect Dis. 2019. PMID: 31236736
Improved survival among ICU-hospitalized patients with community-acquired pneumonia by unidentified organisms: a multicenter case-control study.
Rello J, Diaz E, Mañez R, Sole-Violan J, Valles J, Vidaur L, Zaragoza R, Gattarello S; CAPUCI II Consortium. Rello J, et al. Among authors: vidaur l. Eur J Clin Microbiol Infect Dis. 2017 Jan;36(1):123-130. doi: 10.1007/s10096-016-2779-5. Epub 2016 Sep 21. Eur J Clin Microbiol Infect Dis. 2017. PMID: 27655267
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