Vickers TA - Search Results

1

Insights into innate immune activation via PS-ASO-protein-TLR9 interactions.

Pollak AJ, Zhao L, Vickers TA, Huggins IJ, Liang XH, Crooke ST. Pollak AJ, et al. Among authors: vickers ta. Nucleic Acids Res. 2022 Aug 12;50(14):8107-8126. doi: 10.1093/nar/gkac618. Nucleic Acids Res. 2022. PMID: 35848907 Free PMC article.

2

Efficient and specific knockdown of small non-coding RNAs in mammalian cells and in mice.

Liang XH, Vickers TA, Guo S, Crooke ST. Liang XH, et al. Among authors: vickers ta. Nucleic Acids Res. 2011 Feb;39(3):e13. doi: 10.1093/nar/gkq1121. Epub 2010 Nov 9. Nucleic Acids Res. 2011. PMID: 21062825 Free PMC article.

3

The rates of the major steps in the molecular mechanism of RNase H1-dependent antisense oligonucleotide induced degradation of RNA.

Vickers TA, Crooke ST. Vickers TA, et al. Nucleic Acids Res. 2015 Oct 15;43(18):8955-63. doi: 10.1093/nar/gkv920. Epub 2015 Sep 17. Nucleic Acids Res. 2015. PMID: 26384424 Free PMC article.

4

Acute hepatotoxicity of 2' fluoro-modified 5-10-5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins.

Shen W, De Hoyos CL, Sun H, Vickers TA, Liang XH, Crooke ST. Shen W, et al. Among authors: vickers ta. Nucleic Acids Res. 2018 Mar 16;46(5):2204-2217. doi: 10.1093/nar/gky060. Nucleic Acids Res. 2018. PMID: 29390093 Free PMC article.

5

Cellular uptake mediated by epidermal growth factor receptor facilitates the intracellular activity of phosphorothioate-modified antisense oligonucleotides.

Wang S, Allen N, Vickers TA, Revenko AS, Sun H, Liang XH, Crooke ST. Wang S, et al. Among authors: vickers ta. Nucleic Acids Res. 2018 Apr 20;46(7):3579-3594. doi: 10.1093/nar/gky145. Nucleic Acids Res. 2018. PMID: 29514240 Free PMC article.

6

COPII vesicles can affect the activity of antisense oligonucleotides by facilitating the release of oligonucleotides from endocytic pathways.

Liang XH, Sun H, Nichols JG, Allen N, Wang S, Vickers TA, Shen W, Hsu CW, Crooke ST. Liang XH, et al. Among authors: vickers ta. Nucleic Acids Res. 2018 Nov 2;46(19):10225-10245. doi: 10.1093/nar/gky841. Nucleic Acids Res. 2018. PMID: 30239896 Free PMC article.

7

Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index.

Shen W, De Hoyos CL, Migawa MT, Vickers TA, Sun H, Low A, Bell TA 3rd, Rahdar M, Mukhopadhyay S, Hart CE, Bell M, Riney S, Murray SF, Greenlee S, Crooke RM, Liang XH, Seth PP, Crooke ST. Shen W, et al. Among authors: vickers ta. Nat Biotechnol. 2019 Jun;37(6):640-650. doi: 10.1038/s41587-019-0106-2. Epub 2019 Apr 29. Nat Biotechnol. 2019. PMID: 31036929

8

mRNA levels can be reduced by antisense oligonucleotides via no-go decay pathway.

Liang XH, Nichols JG, Hsu CW, Vickers TA, Crooke ST. Liang XH, et al. Among authors: vickers ta. Nucleic Acids Res. 2019 Jul 26;47(13):6900-6916. doi: 10.1093/nar/gkz500. Nucleic Acids Res. 2019. PMID: 31165876 Free PMC article.

9

Kinetic and subcellular analysis of PS-ASO/protein interactions with P54nrb and RNase H1.

Vickers TA, Rahdar M, Prakash TP, Crooke ST. Vickers TA, et al. Nucleic Acids Res. 2019 Nov 18;47(20):10865-10880. doi: 10.1093/nar/gkz771. Nucleic Acids Res. 2019. PMID: 31495875 Free PMC article.

10

Golgi-endosome transport mediated by M6PR facilitates release of antisense oligonucleotides from endosomes.

Liang XH, Sun H, Hsu CW, Nichols JG, Vickers TA, De Hoyos CL, Crooke ST. Liang XH, et al. Among authors: vickers ta. Nucleic Acids Res. 2020 Feb 20;48(3):1372-1391. doi: 10.1093/nar/gkz1171. Nucleic Acids Res. 2020. PMID: 31840180 Free PMC article.

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