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Eyes on Topical Ocular Disposition: The Considered Design of a Lead Janus Kinase (JAK) Inhibitor That Utilizes a Unique Azetidin-3-Amino Bridging Scaffold to Attenuate Off-Target Kinase Activity, While Driving Potency and Aqueous Solubility.
Gordhan HM, Miller ST, Clancy DC, Ina M, McDougal AV, Cutno DK, Brown RV, Lichorowic CL, Sturdivant JM, Vick KA, Williams SS, deLong MA, White JC, Kopczynski CC, Ellis DA. Gordhan HM, et al. Among authors: vick ka. J Med Chem. 2023 Jul 13;66(13):8929-8950. doi: 10.1021/acs.jmedchem.3c00519. Epub 2023 Jun 14. J Med Chem. 2023. PMID: 37314941