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Antimalarial activity of 4-metoxychalcones: docking studies as falcipain/plasmepsin inhibitors, ADMET and lipophilic efficiency analysis to identify a putative oral lead candidate.
de Oliveira ME, Cenzi G, Nunes RR, Andrighetti CR, de Sousa Valadão DM, Dos Reis C, Simões CM, Nunes RJ, Júnior MC, Taranto AG, Sanchez BA, Viana GH, de Pilla Varotti F. de Oliveira ME, et al. Among authors: viana gh. Molecules. 2013 Dec 10;18(12):15276-87. doi: 10.3390/molecules181215276. Molecules. 2013. PMID: 24335577 Free PMC article.
Improvement of antimalarial activity of a 3-alkylpiridine alkaloid analog by replacing the pyridine ring to a thiazole-containing heterocycle: Mode of action, mutagenicity profile, and Caco-2 cell-based permeability.
Guimarães DSM, de Sousa Luz LS, do Nascimento SB, Silva LR, de Miranda Martins NR, de Almeida HG, de Souza Reis V, Maluf SEC, Budu A, Marinho JA, Abramo C, Carmona AK, da Silva MG, da Silva GR, Kemmer VM, Butera AP, Ribeiro-Viana RM, Gazarini ML, Júnior CSN, Guimarães L, Dos Santos FV, de Castro WV, Viana GHR, de Brito CFA, de Pilla Varotti F. Guimarães DSM, et al. Among authors: viana ghr. Eur J Pharm Sci. 2019 Oct 1;138:105015. doi: 10.1016/j.ejps.2019.105015. Epub 2019 Jul 22. Eur J Pharm Sci. 2019. PMID: 31344442
Synthesis and biological evaluation of novel 3-alkylpyridine marine alkaloid analogs with promising anticancer activity.
Gonçalves AM, de Lima AB, da Silva Barbosa MC, de Camargos LF, de Oliveira JT, de Souza Barbosa C, Villar JA, Costa AC, Silva IV, Silva LM, de Pilla Varotti F, dos Santos FV, Viana GH. Gonçalves AM, et al. Among authors: viana gh. Mar Drugs. 2014 Jul 31;12(8):4361-78. doi: 10.3390/md12084361. Mar Drugs. 2014. PMID: 25089949 Free PMC article.
New quinoline derivatives demonstrate a promising antimalarial activity against Plasmodium falciparum in vitro and Plasmodium berghei in vivo.
Soares RR, da Silva JM, Carlos BC, da Fonseca CC, de Souza LS, Lopes FV, de Paula Dias RM, Moreira PO, Abramo C, Viana GH, de Pila Varotti F, da Silva AD, Scopel KK. Soares RR, et al. Among authors: viana gh. Bioorg Med Chem Lett. 2015 Jun 1;25(11):2308-13. doi: 10.1016/j.bmcl.2015.04.014. Epub 2015 Apr 11. Bioorg Med Chem Lett. 2015. PMID: 25920564
Nanoemulsion composed of 10-(4,5-dihydrothiazol-2-yl)thio)decan-1-ol), a synthetic analog of 3-alkylpiridine marine alkaloid: development, characterization, and antimalarial activity.
Silva MGD, Cardoso JF, Perasoli FB, Branquinho RT, Mourão RS, Tavares HDS, Xocaira MLCT, Guimarães DSM, Viana GHR, Varotti FP, Silva GRD. Silva MGD, et al. Among authors: viana ghr. Eur J Pharm Sci. 2020 Aug 1;151:105382. doi: 10.1016/j.ejps.2020.105382. Epub 2020 May 26. Eur J Pharm Sci. 2020. PMID: 32470575
Metabolic activation enhances the cytotoxicity, genotoxicity and mutagenicity of two synthetic alkaloids with selective effects against human tumour cell lines.
Oliveira JT, Franco FN, Tecchio KB, Gonçalves AMMN, Barbosa CS, Ribeiro RIMA, Viana GHR, Santos VJDSVD, Santos FVD. Oliveira JT, et al. Among authors: viana ghr. Mutat Res Genet Toxicol Environ Mutagen. 2021 Jan-Feb;861-862:503294. doi: 10.1016/j.mrgentox.2020.503294. Epub 2020 Nov 7. Mutat Res Genet Toxicol Environ Mutagen. 2021. PMID: 33551097 Free article.
A 3-alkylpyridine-bearing alkaloid exhibits potent antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) with no detectable resistance.
Herrera KMS, Lopes GFM, Oliveira ME, Sousa JF, Lima WG, Silva FK, Brito JCM, Gomes AJPS, Viana GHR, Soares AC, Ferreira JMS. Herrera KMS, et al. Among authors: viana ghr. Microbiol Res. 2022 Aug;261:127073. doi: 10.1016/j.micres.2022.127073. Epub 2022 May 16. Microbiol Res. 2022. PMID: 35636092 Free article.
Revealing the Binding Process of New 3-Alkylpyridine Marine Alkaloid Analogue Antimalarials and the Heme Group: An Experimental and Theoretical Investigation.
Ribeiro-Viana RM, Butera AP, Santos ES, Tischer CA, Alves RB, Pereira de Freitas R, Guimarães L, Varotti FP, Viana GH, Nascimento CS Jr. Ribeiro-Viana RM, et al. Among authors: viana gh. J Chem Inf Model. 2016 Mar 28;56(3):571-9. doi: 10.1021/acs.jcim.5b00742. Epub 2016 Mar 15. J Chem Inf Model. 2016. PMID: 26954429
12 results