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An agonistic anti-Tie2 antibody suppresses the normal-to-tumor vascular transition in the glioblastoma invasion zone.
Lee E, Lee EA, Kong E, Chon H, Llaiqui-Condori M, Park CH, Park BY, Kang NR, Yoo JS, Lee HS, Kim HS, Park SH, Choi SW, Vestweber D, Lee JH, Kim P, Lee WS, Kim I. Lee E, et al. Among authors: vestweber d. Exp Mol Med. 2023 Feb;55(2):470-484. doi: 10.1038/s12276-023-00939-9. Epub 2023 Feb 24. Exp Mol Med. 2023. PMID: 36828931 Free PMC article.
Sinusoidal and lymphatic vessel growth is controlled by reciprocal VEGF-C-CDH5 inhibition.
Sung DC, Chen M, Dominguez MH, Mahadevan A, Chen X, Yang J, Gao S, Ren AA, Tang AT, Mericko P, Patton R, Lee M, Jannaway M, Nottebaum A, Vestweber D, Scallan JP, Kahn ML. Sung DC, et al. Among authors: vestweber d. Nat Cardiovasc Res. 2022 Nov;1(11):1006-1021. doi: 10.1038/s44161-022-00147-0. Epub 2022 Nov 11. Nat Cardiovasc Res. 2022. PMID: 36910472 Free PMC article.
Tyrosine-protein kinase Yes controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis.
Jin Y, Ding Y, Richards M, Kaakinen M, Giese W, Baumann E, Szymborska A, Rosa A, Nordling S, Schimmel L, Akmeriç EB, Pena A, Nwadozi E, Jamalpour M, Holstein K, Sáinz-Jaspeado M, Bernabeu MO, Welsh M, Gordon E, Franco CA, Vestweber D, Eklund L, Gerhardt H, Claesson-Welsh L. Jin Y, et al. Among authors: vestweber d. Nat Cardiovasc Res. 2022 Dec 7;1(12):1156-1173. doi: 10.1038/s44161-022-00172-z. Nat Cardiovasc Res. 2022. PMID: 37936984 Free PMC article.
E-selectin-mediated rapid NLRP3 inflammasome activation regulates S100A8/S100A9 release from neutrophils via transient gasdermin D pore formation.
Pruenster M, Immler R, Roth J, Kuchler T, Bromberger T, Napoli M, Nussbaumer K, Rohwedder I, Wackerbarth LM, Piantoni C, Hennis K, Fink D, Kallabis S, Schroll T, Masgrau-Alsina S, Budke A, Liu W, Vestweber D, Wahl-Schott C, Roth J, Meissner F, Moser M, Vogl T, Hornung V, Broz P, Sperandio M. Pruenster M, et al. Among authors: vestweber d. Nat Immunol. 2023 Dec;24(12):2021-2031. doi: 10.1038/s41590-023-01656-1. Epub 2023 Oct 30. Nat Immunol. 2023. PMID: 37903858 Free PMC article.
VE-cadherin in arachnoid and pia mater cells serves as a suitable landmark for in vivo imaging of CNS immune surveillance and inflammation.
Mapunda JA, Pareja J, Vladymyrov M, Bouillet E, Hélie P, Pleskač P, Barcos S, Andrae J, Vestweber D, McDonald DM, Betsholtz C, Deutsch U, Proulx ST, Engelhardt B. Mapunda JA, et al. Among authors: vestweber d. Nat Commun. 2023 Sep 20;14(1):5837. doi: 10.1038/s41467-023-41580-4. Nat Commun. 2023. PMID: 37730744 Free PMC article.
An E-cadherin-actin clutch translates the mechanical force of cortical flow for cell-cell contact to inhibit epithelial cell locomotion.
Noordstra I, Hermoso MD, Schimmel L, Bonfim-Melo A, Currin-Ross D, Duong CN, Kalappurakkal JM, Morris RG, Vestweber D, Mayor S, Gordon E, Roca-Cusachs P, Yap AS. Noordstra I, et al. Among authors: vestweber d. Dev Cell. 2023 Sep 25;58(18):1748-1763.e6. doi: 10.1016/j.devcel.2023.06.011. Epub 2023 Jul 21. Dev Cell. 2023. PMID: 37480844
Genetically encoded dual fluorophore reporters for graded oxygen-sensing in light microscopy.
Bauer N, Maisuls I, Pereira da Graça A, Reinhardt D, Erapaneedi R, Kirschnick N, Schäfers M, Grashoff C, Landfester K, Vestweber D, Strassert CA, Kiefer F. Bauer N, et al. Among authors: vestweber d. Biosens Bioelectron. 2023 Feb 1;221:114917. doi: 10.1016/j.bios.2022.114917. Epub 2022 Nov 17. Biosens Bioelectron. 2023. PMID: 36450170 Free article.
Glutamine prevents acute kidney injury by modulating oxidative stress and apoptosis in tubular epithelial cells.
Thomas K, Zondler L, Ludwig N, Kardell M, Lüneburg C, Henke K, Mersmann S, Margraf A, Spieker T, Tekath T, Velic A, Holtmeier R, Hermann J, Jankowski V, Meersch M, Vestweber D, Westphal M, Roth J, Schäfers MA, Kellum JA, Lowell CA, Rossaint J, Zarbock A. Thomas K, et al. Among authors: vestweber d. JCI Insight. 2022 Nov 8;7(21):e163161. doi: 10.1172/jci.insight.163161. JCI Insight. 2022. PMID: 36107633 Free PMC article.
296 results