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Novel phosphoramidate prodrugs of N-acetyl-(D)-glucosamine with antidegenerative activity on bovine and human cartilage explants.
J Med Chem. 2012 May 24;55(10):4629-39. doi: 10.1021/jm300074y. Epub 2012 May 11.
J Med Chem. 2012.
PMID: 22501024
Phosphate prodrugs derived from N-acetylglucosamine have enhanced chondroprotective activity in explant cultures and represent a new lead in antiosteoarthritis drug discovery.
McGuigan C, Serpi M, Bibbo R, Roberts H, Hughes C, Caterson B, Gibert AT, Verson CR.
McGuigan C, et al. Among authors: verson cr.
J Med Chem. 2008 Sep 25;51(18):5807-12. doi: 10.1021/jm800594c. Epub 2008 Aug 21.
J Med Chem. 2008.
PMID: 18714981
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