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Hepatocytes determine the hypoxic microenvironment and radiosensitivity of colorectal cancer cells through production of nitric oxide that targets mitochondrial respiration.
Jiang H, Verovski VN, Leonard W, Law KL, Vermeersch M, Storme G, Van den Berge D, Gevaert T, Sermeus A, De Ridder M. Jiang H, et al. Among authors: verovski vn. Int J Radiat Oncol Biol Phys. 2013 Mar 1;85(3):820-7. doi: 10.1016/j.ijrobp.2012.07.2359. Epub 2012 Sep 11. Int J Radiat Oncol Biol Phys. 2013. PMID: 22975619
Hypoxic tumor cell radiosensitization through nitric oxide.
De Ridder M, Verellen D, Verovski V, Storme G. De Ridder M, et al. Among authors: verovski v. Nitric Oxide. 2008 Sep;19(2):164-9. doi: 10.1016/j.niox.2008.04.015. Epub 2008 Apr 24. Nitric Oxide. 2008. PMID: 18474256 Review.
Activated macrophages as a novel determinant of tumor cell radioresponse: the role of nitric oxide-mediated inhibition of cellular respiration and oxygen sparing.
Jiang H, De Ridder M, Verovski VN, Sonveaux P, Jordan BF, Law K, Monsaert C, Van den Berge DL, Verellen D, Feron O, Gallez B, Storme GA. Jiang H, et al. Among authors: verovski vn. Int J Radiat Oncol Biol Phys. 2010 Apr;76(5):1520-7. doi: 10.1016/j.ijrobp.2009.10.047. Int J Radiat Oncol Biol Phys. 2010. PMID: 20338478
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