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Radiosensitization by Hyperthermia Critically Depends on the Time Interval.
Mei X, Kok HP, Rodermond HM, van Bochove GGW, Snoek BC, van Leeuwen CM, Franken NAP, Ten Hagen TLM, Crezee J, Vermeulen L, Stalpers LJA, Oei AL. Mei X, et al. Among authors: vermeulen l. Int J Radiat Oncol Biol Phys. 2024 Mar 1;118(3):817-828. doi: 10.1016/j.ijrobp.2023.09.048. Epub 2023 Oct 10. Int J Radiat Oncol Biol Phys. 2024. PMID: 37820768
Wnt activity defines colon cancer stem cells and is regulated by the microenvironment.
Vermeulen L, De Sousa E Melo F, van der Heijden M, Cameron K, de Jong JH, Borovski T, Tuynman JB, Todaro M, Merz C, Rodermond H, Sprick MR, Kemper K, Richel DJ, Stassi G, Medema JP. Vermeulen L, et al. Nat Cell Biol. 2010 May;12(5):468-76. doi: 10.1038/ncb2048. Epub 2010 Apr 25. Nat Cell Biol. 2010. PMID: 20418870
Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients.
de Sousa E Melo F, Colak S, Buikhuisen J, Koster J, Cameron K, de Jong JH, Tuynman JB, Prasetyanti PR, Fessler E, van den Bergh SP, Rodermond H, Dekker E, van der Loos CM, Pals ST, van de Vijver MJ, Versteeg R, Richel DJ, Vermeulen L, Medema JP. de Sousa E Melo F, et al. Among authors: vermeulen l. Cell Stem Cell. 2011 Nov 4;9(5):476-85. doi: 10.1016/j.stem.2011.10.008. Cell Stem Cell. 2011. PMID: 22056143 Free article.
Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions.
De Sousa E Melo F, Wang X, Jansen M, Fessler E, Trinh A, de Rooij LP, de Jong JH, de Boer OJ, van Leersum R, Bijlsma MF, Rodermond H, van der Heijden M, van Noesel CJ, Tuynman JB, Dekker E, Markowetz F, Medema JP, Vermeulen L. De Sousa E Melo F, et al. Among authors: vermeulen l. Nat Med. 2013 May;19(5):614-8. doi: 10.1038/nm.3174. Epub 2013 Apr 14. Nat Med. 2013. PMID: 23584090
ER-Stress-Induced Differentiation Sensitizes Colon Cancer Stem Cells to Chemotherapy.
Wielenga MCB, Colak S, Heijmans J, van Lidth de Jeude JF, Rodermond HM, Paton JC, Paton AW, Vermeulen L, Medema JP, van den Brink GR. Wielenga MCB, et al. Among authors: vermeulen l. Cell Rep. 2015 Oct 20;13(3):489-494. doi: 10.1016/j.celrep.2015.09.016. Epub 2015 Oct 8. Cell Rep. 2015. PMID: 26456824 Free article.
Consensus molecular subtypes of colorectal cancer are recapitulated in in vitro and in vivo models.
Linnekamp JF, Hooff SRV, Prasetyanti PR, Kandimalla R, Buikhuisen JY, Fessler E, Ramesh P, Lee KAST, Bochove GGW, de Jong JH, Cameron K, Leersum RV, Rodermond HM, Franitza M, Nürnberg P, Mangiapane LR, Wang X, Clevers H, Vermeulen L, Stassi G, Medema JP. Linnekamp JF, et al. Among authors: vermeulen l. Cell Death Differ. 2018 Mar;25(3):616-633. doi: 10.1038/s41418-017-0011-5. Epub 2018 Jan 5. Cell Death Differ. 2018. PMID: 29305587 Free PMC article.
Pre-Operative Decitabine in Colon Cancer Patients: Analyses on WNT Target Methylation and Expression.
Linnekamp JF, Kandimalla R, Fessler E, de Jong JH, Rodermond HM, van Bochove GGW, The FO, Punt CJA, Bemelman WA, van de Ven AWH, Tanis PJ, Kemper EM, Koens L, Dekker E, Vermeulen L, van Laarhoven HWM, Medema JP. Linnekamp JF, et al. Among authors: vermeulen l. Cancers (Basel). 2021 May 13;13(10):2357. doi: 10.3390/cancers13102357. Cancers (Basel). 2021. PMID: 34068407 Free PMC article.
Exploiting a subtype-specific mitochondrial vulnerability for successful treatment of colorectal peritoneal metastases.
Bootsma S, Dings MPG, Kesselaar J, Helderman RFCPA, van Megesen K, Constantinides A, Moreno LF, Stelloo E, Scutigliani EM, Bokan B, Torang A, van Hooff SR, Zwijnenburg DA, Wouters VM, van de Vlasakker VCJ, Galanos LJK, Nijman LE, Logiantara A, Veenstra VL, Schlingemann S, van Piggelen S, van der Wel N, Krawczyk PM, Platteeuw JJ, Tuynman JB, de Hingh IH, Klomp JPG, Oubrie A, Snaebjornsson P, Medema JP, Oei AL, Kranenburg O, Elbers CC, Lenos KJ, Vermeulen L, Bijlsma MF. Bootsma S, et al. Among authors: vermeulen l. Cell Rep Med. 2024 Apr 22:101523. doi: 10.1016/j.xcrm.2024.101523. Online ahead of print. Cell Rep Med. 2024. PMID: 38670098 Free article.
A multidimensional network approach reveals microRNAs as determinants of the mesenchymal colorectal cancer subtype.
Fessler E, Jansen M, De Sousa E Melo F, Zhao L, Prasetyanti PR, Rodermond H, Kandimalla R, Linnekamp JF, Franitza M, van Hooff SR, de Jong JH, Oppeneer SC, van Noesel CJ, Dekker E, Stassi G, Wang X, Medema JP, Vermeulen L. Fessler E, et al. Among authors: vermeulen l. Oncogene. 2016 Nov 17;35(46):6026-6037. doi: 10.1038/onc.2016.134. Epub 2016 May 9. Oncogene. 2016. PMID: 27157610 Free PMC article.
349 results