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Excessive proteostasis contributes to pathology in fragile X syndrome.
Neuron. 2023 Feb 15;111(4):508-525.e7. doi: 10.1016/j.neuron.2022.11.012. Epub 2022 Dec 9.
Neuron. 2023.
PMID: 36495869
Free article.
Excess ribosomal protein production unbalances translation in a model of Fragile X Syndrome.
Seo SS, Louros SR, Anstey N, Gonzalez-Lozano MA, Harper CB, Verity NC, Dando O, Thomson SR, Darnell JC, Kind PC, Li KW, Osterweil EK.
Seo SS, et al. Among authors: verity nc.
Nat Commun. 2022 Jun 10;13(1):3236. doi: 10.1038/s41467-022-30979-0.
Nat Commun. 2022.
PMID: 35688821
Free PMC article.
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Targeting the kinase insert loop of PERK selectively modulates PERK signaling without systemic toxicity in mice.
Hughes DT, Halliday M, Smith HL, Verity NC, Molloy C, Radford H, Butcher AJ, Mallucci GR.
Hughes DT, et al. Among authors: verity nc.
Sci Signal. 2020 Aug 11;13(644):eabb4749. doi: 10.1126/scisignal.abb4749.
Sci Signal. 2020.
PMID: 32788341
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Astrocyte Unfolded Protein Response Induces a Specific Reactivity State that Causes Non-Cell-Autonomous Neuronal Degeneration.
Smith HL, Freeman OJ, Butcher AJ, Holmqvist S, Humoud I, Schätzl T, Hughes DT, Verity NC, Swinden DP, Hayes J, de Weerd L, Rowitch DH, Franklin RJM, Mallucci GR.
Smith HL, et al. Among authors: verity nc.
Neuron. 2020 Mar 4;105(5):855-866.e5. doi: 10.1016/j.neuron.2019.12.014. Epub 2020 Jan 7.
Neuron. 2020.
PMID: 31924446
Free PMC article.
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Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice.
Halliday M, Radford H, Zents KAM, Molloy C, Moreno JA, Verity NC, Smith E, Ortori CA, Barrett DA, Bushell M, Mallucci GR.
Halliday M, et al. Among authors: verity nc.
Brain. 2017 Jun 1;140(6):1768-1783. doi: 10.1093/brain/awx074.
Brain. 2017.
PMID: 28430857
Free PMC article.
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Rescuing neurons in prion disease.
Verity NC, Mallucci GR.
Verity NC, et al.
Biochem J. 2011 Jan 1;433(1):19-29. doi: 10.1042/BJ20101323.
Biochem J. 2011.
PMID: 21158739
Review.
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