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Synthesis of (hetero)arylated pyridazin-3(2H)-ones via Negishi reaction involving zincated pyridazin-3(2H)-ones.
J Org Chem. 2011 Dec 2;76(23):9648-59. doi: 10.1021/jo201587j. Epub 2011 Nov 9.
J Org Chem. 2011.
PMID: 22017314
2-Substituted 4-, 5-, and 6-[(1E)-3-oxo-3-phenylprop-1-en-1-yl]pyridazin-3(2H)-ones and 2-substituted 4,5-bis[(1E)-3-oxo-3-phenylprop-1-en-1-yl]pyridazin-3(2H)-ones as potent platelet aggregation inhibitors: design, synthesis, and SAR studies.
Meyers C, Yáñez M, Elmaatougi A, Verhelst T, Coelho A, Fraiz N, Lemière GL, García-Mera X, Laguna R, Cano E, Maes BU, Sotelo E.
Meyers C, et al. Among authors: verhelst t.
Bioorg Med Chem Lett. 2008 Jan 15;18(2):793-7. doi: 10.1016/j.bmcl.2007.11.034. Epub 2007 Nov 17.
Bioorg Med Chem Lett. 2008.
PMID: 18053717
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Synthesis of functionalized pyridazin-3(2H)-ones via bromine-magnesium exchange on bromopyridazin-3(2H)-ones.
Ryabtsova O, Verhelst T, Baeten M, Vande Velde CM, Maes BU.
Ryabtsova O, et al. Among authors: verhelst t.
J Org Chem. 2009 Dec 18;74(24):9440-5. doi: 10.1021/jo9020985.
J Org Chem. 2009.
PMID: 19928756
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Synthesis of functionalized pyridazin-3(2H)-ones via nucleophilic substitution of hydrogen (SNH).
Verhelst T, Verbeeck S, Ryabtsova O, Depraetere S, Maes BU.
Verhelst T, et al.
Org Lett. 2011 Jan 21;13(2):272-5. doi: 10.1021/ol102703w. Epub 2010 Dec 7.
Org Lett. 2011.
PMID: 21138319
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Synthesis of functionalized pyridazin-3(2H)-ones via selective bromine-magnesium exchange and lactam directed ortho C-H magnesiation.
Verhelst T, Maes J, Liu Z, Sergeyev S, Maes BU.
Verhelst T, et al.
J Org Chem. 2011 Aug 19;76(16):6670-7. doi: 10.1021/jo201009m. Epub 2011 Jul 20.
J Org Chem. 2011.
PMID: 21732644
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Oxidative Addition of Haloheteroarenes to Palladium(0): Concerted versus SN Ar-Type Mechanism.
Maes BU, Verbeeck S, Verhelst T, Ekomié A, von Wolff N, Lefèvre G, Mitchell EA, Jutand A.
Maes BU, et al. Among authors: verhelst t.
Chemistry. 2015 May 18;21(21):7858-65. doi: 10.1002/chem.201406210. Epub 2015 Apr 8.
Chemistry. 2015.
PMID: 25858175
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