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A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate.
Sanchez-Felipe L, Vercruysse T, Sharma S, Ma J, Lemmens V, Van Looveren D, Arkalagud Javarappa MP, Boudewijns R, Malengier-Devlies B, Liesenborghs L, Kaptein SJF, De Keyzer C, Bervoets L, Debaveye S, Rasulova M, Seldeslachts L, Li LH, Jansen S, Yakass MB, Verstrepen BE, Böszörményi KP, Kiemenyi-Kayere G, van Driel N, Quaye O, Zhang X, Ter Horst S, Mishra N, Deboutte W, Matthijnssens J, Coelmont L, Vandermeulen C, Heylen E, Vergote V, Schols D, Wang Z, Bogers W, Kuiken T, Verschoor E, Cawthorne C, Van Laere K, Opdenakker G, Vande Velde G, Weynand B, Teuwen DE, Matthys P, Neyts J, Jan Thibaut H, Dallmeier K. Sanchez-Felipe L, et al. Among authors: vergote v. Nature. 2021 Feb;590(7845):320-325. doi: 10.1038/s41586-020-3035-9. Epub 2020 Dec 1. Nature. 2021. PMID: 33260195
Favipiravir at high doses has potent antiviral activity in SARS-CoV-2-infected hamsters, whereas hydroxychloroquine lacks activity.
Kaptein SJF, Jacobs S, Langendries L, Seldeslachts L, Ter Horst S, Liesenborghs L, Hens B, Vergote V, Heylen E, Barthelemy K, Maas E, De Keyzer C, Bervoets L, Rymenants J, Van Buyten T, Zhang X, Abdelnabi R, Pang J, Williams R, Thibaut HJ, Dallmeier K, Boudewijns R, Wouters J, Augustijns P, Verougstraete N, Cawthorne C, Breuer J, Solas C, Weynand B, Annaert P, Spriet I, Vande Velde G, Neyts J, Rocha-Pereira J, Delang L. Kaptein SJF, et al. Among authors: vergote v. Proc Natl Acad Sci U S A. 2020 Oct 27;117(43):26955-26965. doi: 10.1073/pnas.2014441117. Epub 2020 Oct 9. Proc Natl Acad Sci U S A. 2020. PMID: 33037151 Free PMC article.
STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters.
Boudewijns R, Thibaut HJ, Kaptein SJF, Li R, Vergote V, Seldeslachts L, Van Weyenbergh J, De Keyzer C, Bervoets L, Sharma S, Liesenborghs L, Ma J, Jansen S, Van Looveren D, Vercruysse T, Wang X, Jochmans D, Martens E, Roose K, De Vlieger D, Schepens B, Van Buyten T, Jacobs S, Liu Y, Martí-Carreras J, Vanmechelen B, Wawina-Bokalanga T, Delang L, Rocha-Pereira J, Coelmont L, Chiu W, Leyssen P, Heylen E, Schols D, Wang L, Close L, Matthijnssens J, Van Ranst M, Compernolle V, Schramm G, Van Laere K, Saelens X, Callewaert N, Opdenakker G, Maes P, Weynand B, Cawthorne C, Vande Velde G, Wang Z, Neyts J, Dallmeier K. Boudewijns R, et al. Among authors: vergote v. Nat Commun. 2020 Nov 17;11(1):5838. doi: 10.1038/s41467-020-19684-y. Nat Commun. 2020. PMID: 33203860 Free PMC article.
The combined treatment of Molnupiravir and Favipiravir results in a potentiation of antiviral efficacy in a SARS-CoV-2 hamster infection model.
Abdelnabi R, Foo CS, Kaptein SJF, Zhang X, Do TND, Langendries L, Vangeel L, Breuer J, Pang J, Williams R, Vergote V, Heylen E, Leyssen P, Dallmeier K, Coelmont L, Chatterjee AK, Mols R, Augustijns P, De Jonghe S, Jochmans D, Weynand B, Neyts J. Abdelnabi R, et al. Among authors: vergote v. EBioMedicine. 2021 Oct;72:103595. doi: 10.1016/j.ebiom.2021.103595. Epub 2021 Sep 24. EBioMedicine. 2021. PMID: 34571361 Free PMC article.
HIV protease inhibitors Nelfinavir and Lopinavir/Ritonavir markedly improve lung pathology in SARS-CoV-2-infected Syrian hamsters despite lack of an antiviral effect.
Foo CS, Abdelnabi R, Kaptein SJF, Zhang X, Ter Horst S, Mols R, Delang L, Rocha-Pereira J, Coelmont L, Leyssen P, Dallmeier K, Vergote V, Heylen E, Vangeel L, Chatterjee AK, Annaert PP, Augustijns PF, De Jonghe S, Jochmans D, Gouwy M, Cambier S, Vandooren J, Proost P, van Laer C, Weynand B, Neyts J. Foo CS, et al. Among authors: vergote v. Antiviral Res. 2022 Jun;202:105311. doi: 10.1016/j.antiviral.2022.105311. Epub 2022 Apr 4. Antiviral Res. 2022. PMID: 35390430 Free PMC article.
Discovery and genome characterization of three new Jeilongviruses, a lineage of paramyxoviruses characterized by their unique membrane proteins.
Vanmechelen B, Bletsa M, Laenen L, Lopes AR, Vergote V, Beller L, Deboutte W, Korva M, Avšič Županc T, Goüy de Bellocq J, Gryseels S, Leirs H, Lemey P, Vrancken B, Maes P. Vanmechelen B, et al. Among authors: vergote v. BMC Genomics. 2018 Aug 16;19(1):617. doi: 10.1186/s12864-018-4995-0. BMC Genomics. 2018. PMID: 30115009 Free PMC article.
Convalescent plasma treatment of persistent severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in patients with lymphoma with impaired humoral immunity and lack of neutralising antibodies.
Betrains A, Godinas L, Woei-A-Jin FJSH, Rosseels W, Van Herck Y, Lorent N, Dierickx D, Compernolle V, Meyfroidt G, Vanderbeke L, Vergote V, Lagrou K, Verhamme P, Wauters J, Vermeersch P, Devos T, Maes P, Vanderschueren S. Betrains A, et al. Among authors: vergote v. Br J Haematol. 2021 Mar;192(6):1100-1105. doi: 10.1111/bjh.17266. Epub 2020 Dec 13. Br J Haematol. 2021. PMID: 33314018 Free article. No abstract available.
A Novel Hantavirus of the European Mole, Bruges Virus, Is Involved in Frequent Nova Virus Coinfections.
Laenen L, Vergote V, Kafetzopoulou LE, Wawina TB, Vassou D, Cook JA, Hugot JP, Deboutte W, Kang HJ, Witkowski PT, Köppen-Rung P, Krüger DH, Licková M, Stang A, Striešková L, Szemeš T, Markowski J, Hejduk J, Kafetzopoulos D, Van Ranst M, Yanagihara R, Klempa B, Maes P. Laenen L, et al. Among authors: vergote v. Genome Biol Evol. 2018 Jan 1;10(1):45-55. doi: 10.1093/gbe/evx268. Genome Biol Evol. 2018. PMID: 29272370 Free PMC article.
61 results