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Mirror-image ligand discovery enabled by single-shot fast-flow synthesis of D-proteins.
Callahan AJ, Gandhesiri S, Travaline TL, Reja RM, Lozano Salazar L, Hanna S, Lee YC, Li K, Tokareva OS, Swiecicki JM, Loas A, Verdine GL, McGee JH, Pentelute BL. Callahan AJ, et al. Among authors: verdine gl. Nat Commun. 2024 Feb 28;15(1):1813. doi: 10.1038/s41467-024-45634-z. Nat Commun. 2024. PMID: 38418820 Free PMC article.
De novo mapping of α-helix recognition sites on protein surfaces using unbiased libraries.
Li K, Tokareva OS, Thomson TM, Wahl SCT, Travaline TL, Ramirez JD, Choudary SK, Agarwal S, Walkup WG 4th, Olsen TJ, Brennan MJ, Verdine GL, McGee JH. Li K, et al. Among authors: verdine gl. Proc Natl Acad Sci U S A. 2022 Dec 27;119(52):e2210435119. doi: 10.1073/pnas.2210435119. Epub 2022 Dec 19. Proc Natl Acad Sci U S A. 2022. PMID: 36534810 Free PMC article.
Exceptionally high-affinity Ras binders that remodel its effector domain.
McGee JH, Shim SY, Lee SJ, Swanson PK, Jiang SY, Durney MA, Verdine GL. McGee JH, et al. Among authors: verdine gl. J Biol Chem. 2018 Mar 2;293(9):3265-3280. doi: 10.1074/jbc.M117.816348. Epub 2017 Dec 27. J Biol Chem. 2018. PMID: 29282294 Free PMC article.
An engineered protein antagonist of K-Ras/B-Raf interaction.
Kauke MJ, Traxlmayr MW, Parker JA, Kiefer JD, Knihtila R, McGee J, Verdine G, Mattos C, Wittrup KD. Kauke MJ, et al. Sci Rep. 2017 Jul 19;7(1):5831. doi: 10.1038/s41598-017-05889-7. Sci Rep. 2017. PMID: 28724936 Free PMC article.
Direct inhibition of the NOTCH transcription factor complex.
Moellering RE, Cornejo M, Davis TN, Del Bianco C, Aster JC, Blacklow SC, Kung AL, Gilliland DG, Verdine GL, Bradner JE. Moellering RE, et al. Among authors: verdine gl. Nature. 2009 Nov 12;462(7270):182-8. doi: 10.1038/nature08543. Nature. 2009. PMID: 19907488 Free PMC article.
174 results