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A trypanosome-derived immunotherapeutics platform elicits potent high-affinity antibodies, negating the effects of the synthetic opioid fentanyl.
Triller G, Vlachou EP, Hashemi H, van Straaten M, Zeelen JP, Kelemen Y, Baehr C, Marker CL, Ruf S, Svirina A, Chandra M, Urban K, Gkeka A, Kruse S, Baumann A, Miller AK, Bartel M, Pravetoni M, Stebbins CE, Papavasiliou FN, Verdi JP. Triller G, et al. Among authors: verdi jp. Cell Rep. 2023 Feb 28;42(2):112049. doi: 10.1016/j.celrep.2023.112049. Epub 2023 Jan 30. Cell Rep. 2023. PMID: 36719797 Free PMC article.
Rapid, adaptable and sensitive Cas13-based COVID-19 diagnostics using ADESSO.
Casati B, Verdi JP, Hempelmann A, Kittel M, Klaebisch AG, Meister B, Welker S, Asthana S, Di Giorgio S, Boskovic P, Man KH, Schopp M, Ginno PA, Radlwimmer B, Stebbins CE, Miethke T, Papavasiliou FN, Pecori R. Casati B, et al. Among authors: verdi jp. Nat Commun. 2022 Jun 8;13(1):3308. doi: 10.1038/s41467-022-30862-y. Nat Commun. 2022. PMID: 35676259 Free PMC article.
Immunodominant surface epitopes power immune evasion in the African trypanosome.
Gkeka A, Aresta-Branco F, Triller G, Vlachou EP, van Straaten M, Lilic M, Olinares PDB, Perez K, Chait BT, Blatnik R, Ruppert T, Verdi JP, Stebbins CE, Papavasiliou FN. Gkeka A, et al. Among authors: verdi jp. Cell Rep. 2023 Mar 28;42(3):112262. doi: 10.1016/j.celrep.2023.112262. Epub 2023 Mar 20. Cell Rep. 2023. PMID: 36943866 Free article.
A structural classification of the variant surface glycoproteins of the African trypanosome.
Đaković S, Zeelen JP, Gkeka A, Chandra M, van Straaten M, Foti K, Zhong J, Vlachou EP, Aresta-Branco F, Verdi JP, Papavasiliou FN, Stebbins CE. Đaković S, et al. Among authors: verdi jp. PLoS Negl Trop Dis. 2023 Sep 1;17(9):e0011621. doi: 10.1371/journal.pntd.0011621. eCollection 2023 Sep. PLoS Negl Trop Dis. 2023. PMID: 37656766 Free PMC article.
The fentanyl-specific antibody FenAb024 can shield against carfentanil effects.
Urban K, Gkeka A, Chandra M, Greiner D, Pollich S, Ruf S, Kelemen Y, Sundermann T, Pravetoni M, Baehr C, Stebbins CE, Papavasiliou FN, Verdi JP. Urban K, et al. Among authors: verdi jp. Toxicol Lett. 2024 Apr 6;396:1-10. doi: 10.1016/j.toxlet.2024.03.008. Online ahead of print. Toxicol Lett. 2024. PMID: 38588756 Free article.