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Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+ T cells.
Matas-Rico E, Frijlink E, van der Haar Àvila I, Menegakis A, van Zon M, Morris AJ, Koster J, Salgado-Polo F, de Kivit S, Lança T, Mazzocca A, Johnson Z, Haanen J, Schumacher TN, Perrakis A, Verbrugge I, van den Berg JH, Borst J, Moolenaar WH. Matas-Rico E, et al. Among authors: verbrugge i. Cell Rep. 2021 Nov 16;37(7):110013. doi: 10.1016/j.celrep.2021.110013. Cell Rep. 2021. PMID: 34788605 Free PMC article.
Concomitant targeting of programmed death-1 (PD-1) and CD137 improves the efficacy of radiotherapy in a mouse model of human BRAFV600-mutant melanoma.
Kroon P, Gadiot J, Peeters M, Gasparini A, Deken MA, Yagita H, Verheij M, Borst J, Blank CU, Verbrugge I. Kroon P, et al. Among authors: verbrugge i. Cancer Immunol Immunother. 2016 Jun;65(6):753-63. doi: 10.1007/s00262-016-1843-4. Epub 2016 May 9. Cancer Immunol Immunother. 2016. PMID: 27160390 Free PMC article.
Ubiquitination by the membrane-associated RING-CH-8 (MARCH-8) ligase controls steady-state cell surface expression of tumor necrosis factor-related apoptosis inducing ligand (TRAIL) receptor 1.
van de Kooij B, Verbrugge I, de Vries E, Gijsen M, Montserrat V, Maas C, Neefjes J, Borst J. van de Kooij B, et al. Among authors: verbrugge i. J Biol Chem. 2013 Mar 1;288(9):6617-28. doi: 10.1074/jbc.M112.448209. Epub 2013 Jan 8. J Biol Chem. 2013. PMID: 23300075 Free PMC article.
Combining radiotherapy with APO010 in cancer treatment.
Verbrugge I, Wissink EH, Rooswinkel RW, Jongsma J, Beltraminelli N, Dupuis M, Borst J, Verheij M. Verbrugge I, et al. Clin Cancer Res. 2009 Mar 15;15(6):2031-8. doi: 10.1158/1078-0432.CCR-08-2125. Epub 2009 Mar 10. Clin Cancer Res. 2009. PMID: 19276268
26 results