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Changing POU dimerization preferences converts Oct6 into a pluripotency inducer.
Jerabek S, Ng CK, Wu G, Arauzo-Bravo MJ, Kim KP, Esch D, Malik V, Chen Y, Velychko S, MacCarthy CM, Yang X, Cojocaru V, Schöler HR, Jauch R. Jerabek S, et al. Among authors: velychko s. EMBO Rep. 2017 Feb;18(2):319-333. doi: 10.15252/embr.201642958. Epub 2016 Dec 22. EMBO Rep. 2017. PMID: 28007765 Free PMC article.
Reprogramming competence of OCT factors is determined by transactivation domains.
Kim KP, Wu Y, Yoon J, Adachi K, Wu G, Velychko S, MacCarthy CM, Shin B, Röpke A, Arauzo-Bravo MJ, Stehling M, Han DW, Gao Y, Kim J, Gao S, Schöler HR. Kim KP, et al. Among authors: velychko s. Sci Adv. 2020 Sep 2;6(36):eaaz7364. doi: 10.1126/sciadv.aaz7364. Print 2020 Sep. Sci Adv. 2020. PMID: 32917606 Free PMC article.
Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors.
Ehrlich M, Mozafari S, Glatza M, Starost L, Velychko S, Hallmann AL, Cui QL, Schambach A, Kim KP, Bachelin C, Marteyn A, Hargus G, Johnson RM, Antel J, Sterneckert J, Zaehres H, Schöler HR, Baron-Van Evercooren A, Kuhlmann T. Ehrlich M, et al. Among authors: velychko s. Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):E2243-E2252. doi: 10.1073/pnas.1614412114. Epub 2017 Feb 28. Proc Natl Acad Sci U S A. 2017. PMID: 28246330 Free PMC article.
Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox2.
Malik V, Glaser LV, Zimmer D, Velychko S, Weng M, Holzner M, Arend M, Chen Y, Srivastava Y, Veerapandian V, Shah Z, Esteban MA, Wang H, Chen J, Schöler HR, Hutchins AP, Meijsing SH, Pott S, Jauch R. Malik V, et al. Among authors: velychko s. Nat Commun. 2019 Aug 2;10(1):3477. doi: 10.1038/s41467-019-11054-7. Nat Commun. 2019. PMID: 31375664 Free PMC article.
Directed Evolution of an Enhanced POU Reprogramming Factor for Cell Fate Engineering.
Tan DS, Chen Y, Gao Y, Bednarz A, Wei Y, Malik V, Ho DH, Weng M, Ho SY, Srivastava Y, Velychko S, Yang X, Fan L, Kim J, Graumann J, Stormo GD, Braun T, Yan J, Schöler HR, Jauch R. Tan DS, et al. Among authors: velychko s. Mol Biol Evol. 2021 Jun 25;38(7):2854-2868. doi: 10.1093/molbev/msab075. Mol Biol Evol. 2021. PMID: 33720298 Free PMC article.
One-step Reprogramming of Human Fibroblasts into Oligodendrocyte-like Cells by SOX10, OLIG2, and NKX6.2.
Chanoumidou K, Hernández-Rodríguez B, Windener F, Thomas C, Stehling M, Mozafari S, Albrecht S, Ottoboni L, Antel J, Kim KP, Velychko S, Cui QL, Xu YKT, Martino G, Winkler J, Schöler HR, Baron-Van Evercooren A, Boespflug-Tanguy O, Vaquerizas JM, Ehrlich M, Kuhlmann T. Chanoumidou K, et al. Among authors: velychko s. Stem Cell Reports. 2021 Apr 13;16(4):771-783. doi: 10.1016/j.stemcr.2021.03.001. Epub 2021 Mar 25. Stem Cell Reports. 2021. PMID: 33770499 Free PMC article.
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