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Regulatory T-cell Depletion Alters the Tumor Microenvironment and Accelerates Pancreatic Carcinogenesis.
Cancer Discov. 2020 Mar;10(3):422-439. doi: 10.1158/2159-8290.CD-19-0958. Epub 2020 Jan 7.
Cancer Discov. 2020.
PMID: 31911451
Free PMC article.
Apolipoprotein E Promotes Immune Suppression in Pancreatic Cancer through NF-κB-Mediated Production of CXCL1.
Kemp SB, Carpenter ES, Steele NG, Donahue KL, Nwosu ZC, Pacheco A, Velez-Delgado A, Menjivar RE, Lima F, The S, Espinoza CE, Brown K, Long D, Lyssiotis CA, Rao A, Zhang Y, Pasca di Magliano M, Crawford HC.
Kemp SB, et al. Among authors: velez delgado a.
Cancer Res. 2021 Aug 15;81(16):4305-4318. doi: 10.1158/0008-5472.CAN-20-3929. Epub 2021 May 28.
Cancer Res. 2021.
PMID: 34049975
Free PMC article.
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Extrinsic KRAS Signaling Shapes the Pancreatic Microenvironment Through Fibroblast Reprogramming.
Velez-Delgado A, Donahue KL, Brown KL, Du W, Irizarry-Negron V, Menjivar RE, Lasse Opsahl EL, Steele NG, The S, Lazarus J, Sirihorachai VR, Yan W, Kemp SB, Kerk SA, Bollampally M, Yang S, Scales MK, Avritt FR, Lima F, Lyssiotis CA, Rao A, Crawford HC, Bednar F, Frankel TL, Allen BL, Zhang Y, Pasca di Magliano M.
Velez-Delgado A, et al.
Cell Mol Gastroenterol Hepatol. 2022;13(6):1673-1699. doi: 10.1016/j.jcmgh.2022.02.016. Epub 2022 Mar 1.
Cell Mol Gastroenterol Hepatol. 2022.
PMID: 35245687
Free PMC article.
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WNT signaling in the tumor microenvironment promotes immunosuppression in murine pancreatic cancer.
Du W, Menjivar RE, Donahue KL, Kadiyala P, Velez-Delgado A, Brown KL, Watkoske HR, He X, Carpenter ES, Angeles CV, Zhang Y, Pasca di Magliano M.
Du W, et al. Among authors: velez delgado a.
J Exp Med. 2023 Jan 2;220(1):e20220503. doi: 10.1084/jem.20220503. Epub 2022 Oct 14.
J Exp Med. 2023.
PMID: 36239683
Free PMC article.
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Combinatorial Gli activity directs immune infiltration and tumor growth in pancreatic cancer.
Scales MK, Velez-Delgado A, Steele NG, Schrader HE, Stabnick AM, Yan W, Mercado Soto NM, Nwosu ZC, Johnson C, Zhang Y, Salas-Escabillas DJ, Menjivar RE, Maurer HC, Crawford HC, Bednar F, Olive KP, Pasca di Magliano M, Allen BL.
Scales MK, et al. Among authors: velez delgado a.
PLoS Genet. 2022 Jul 22;18(7):e1010315. doi: 10.1371/journal.pgen.1010315. eCollection 2022 Jul.
PLoS Genet. 2022.
PMID: 35867772
Free PMC article.
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Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer.
Zhang Y, Velez-Delgado A, Mathew E, Li D, Mendez FM, Flannagan K, Rhim AD, Simeone DM, Beatty GL, Pasca di Magliano M.
Zhang Y, et al. Among authors: velez delgado a.
Gut. 2017 Jan;66(1):124-136. doi: 10.1136/gutjnl-2016-312078. Epub 2016 Jul 8.
Gut. 2017.
PMID: 27402485
Free PMC article.
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Arginase 1 is a key driver of immune suppression in pancreatic cancer.
Menjivar RE, Nwosu ZC, Du W, Donahue KL, Hong HS, Espinoza C, Brown K, Velez-Delgado A, Yan W, Lima F, Bischoff A, Kadiyala P, Salas-Escabillas D, Crawford HC, Bednar F, Carpenter E, Zhang Y, Halbrook CJ, Lyssiotis CA, Pasca di Magliano M.
Menjivar RE, et al. Among authors: velez delgado a.
Elife. 2023 Feb 2;12:e80721. doi: 10.7554/eLife.80721.
Elife. 2023.
PMID: 36727849
Free PMC article.
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