Velazquez CA - Search Results

1

NO-releasing NSAIDs suppress NF-κB signaling in vitro and in vivo through S-nitrosylation.

Chattopadhyay M, Goswami S, Rodes DB, Kodela R, Velazquez CA, Boring D, Crowell JA, Kashfi K. Chattopadhyay M, et al. Among authors: velazquez ca. Cancer Lett. 2010 Dec 8;298(2):204-11. doi: 10.1016/j.canlet.2010.07.006. Epub 2010 Jul 31. Cancer Lett. 2010. PMID: 20674154

2

Comparison between 3-Nitrooxyphenyl acetylsalicylate (NO-ASA) and O2-(acetylsalicyloxymethyl)-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (NONO-ASA) as safe anti-inflammatory, analgesic, antipyretic, antioxidant prodrugs.

Chattopadhyay M, Velazquez CA, Pruski A, Nia KV, Abdellatif KR, Keefer LK, Kashfi K. Chattopadhyay M, et al. Among authors: velazquez ca. J Pharmacol Exp Ther. 2010 Nov;335(2):443-50. doi: 10.1124/jpet.110.171017. Epub 2010 Aug 2. J Pharmacol Exp Ther. 2010. PMID: 20679133 Free PMC article.

3

Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: synthesis, biological evaluation and nitric oxide release studies.

Abdellatif KR, Chowdhury MA, Dong Y, Das D, Yu G, Velázquez CA, Suresh MR, Knaus EE. Abdellatif KR, et al. Among authors: velazquez ca. Bioorg Med Chem Lett. 2009 Jun 1;19(11):3014-8. doi: 10.1016/j.bmcl.2009.04.059. Epub 2009 Apr 20. Bioorg Med Chem Lett. 2009. PMID: 19419861

4

O2-acetoxymethyl-protected diazeniumdiolate-based NSAIDs (NONO-NSAIDs): synthesis, nitric oxide release, and biological evaluation studies.

Velázquez CA, Praveen Rao PN, Citro ML, Keefer LK, Knaus EE. Velázquez CA, et al. Bioorg Med Chem. 2007 Jul 15;15(14):4767-74. doi: 10.1016/j.bmc.2007.05.009. Epub 2007 May 6. Bioorg Med Chem. 2007. PMID: 17509888 Free PMC article.

5

Ethanesulfohydroxamic acid ester prodrugs of nonsteroidal anti-inflammatory drugs (NSAIDs): synthesis, nitric oxide and nitroxyl release, cyclooxygenase inhibition, anti-inflammatory, and ulcerogenicity index studies.

Huang Z, Velázquez CA, Abdellatif KR, Chowdhury MA, Reisz JA, DuMond JF, King SB, Knaus EE. Huang Z, et al. Among authors: velazquez ca. J Med Chem. 2011 Mar 10;54(5):1356-64. doi: 10.1021/jm101403g. Epub 2011 Jan 31. J Med Chem. 2011. PMID: 21280601

6

Syntheses, calcium channel agonist-antagonist modulation activities, and nitric oxide release studies of nitrooxyalkyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-(2,1,3-benzoxadiazol-4-yl)pyridine-5-carboxylate racemates, enantiomers, and diastereomers.

Shan R, Velazquez C, Knaus EE. Shan R, et al. J Med Chem. 2004 Jan 1;47(1):254-61. doi: 10.1021/jm030333h. J Med Chem. 2004. PMID: 14695839

7

Synthesis and biological evaluation of 1,4-dihydropyridine calcium channel modulators having a diazen-1-ium-1,2-diolate nitric oxide donor moiety for the potential treatment of congestive heart failure.

Velázquez C, Knaus EE. Velázquez C, et al. Bioorg Med Chem. 2004 Jul 15;12(14):3831-40. doi: 10.1016/j.bmc.2004.05.008. Bioorg Med Chem. 2004. PMID: 15210150

8

Hantzsch 1,4-dihydropyridines containing a diazen-1-ium-1,2-diolate nitric oxide donor moiety to study calcium channel antagonist structure-activity relationships and nitric oxide release.

Nguyen JT, Velázquez CA, Knaus EE. Nguyen JT, et al. Among authors: velazquez ca. Bioorg Med Chem. 2005 Mar 1;13(5):1725-38. doi: 10.1016/j.bmc.2004.12.002. Bioorg Med Chem. 2005. PMID: 15698790

9

Synthesis and biological evaluation of 3,4-diphenyl-1,2,5-oxadiazole-2-oxides and 3,4-diphenyl-1,2,5-oxadiazoles as potential hybrid COX-2 inhibitor/nitric oxide donor agents.

Velázquez C, Rao PN, McDonald R, Knaus EE. Velázquez C, et al. Bioorg Med Chem. 2005 Apr 15;13(8):2749-57. doi: 10.1016/j.bmc.2005.02.034. Bioorg Med Chem. 2005. PMID: 15781386

10

Design and synthesis of alkyl 7,7-dihalo-3-methyl-5-(nitrophenyl)-2-azabicyclo[4.1.0]hept-3-ene-4-carboxylates with calcium channel antagonist activity.

Mojarrad JS, Vo D, Velázquez C, Knaus EE. Mojarrad JS, et al. Bioorg Med Chem. 2005 Jun 2;13(12):4085-91. doi: 10.1016/j.bmc.2005.03.047. Bioorg Med Chem. 2005. PMID: 15911322

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