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α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity.
Ghanem SS, Majbour NK, Vaikath NN, Ardah MT, Erskine D, Jensen NM, Fayyad M, Sudhakaran IP, Vasili E, Melachroinou K, Abdi IY, Poggiolini I, Santos P, Dorn A, Carloni P, Vekrellis K, Attems J, McKeith I, Outeiro TF, Jensen PH, El-Agnaf OMA. Ghanem SS, et al. Among authors: vekrellis k. Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2109617119. doi: 10.1073/pnas.2109617119. Epub 2022 Mar 30. Proc Natl Acad Sci U S A. 2022. PMID: 35353605 Free PMC article.
Neurobiology of alpha-synuclein.
Vekrellis K, Rideout HJ, Stefanis L. Vekrellis K, et al. Mol Neurobiol. 2004 Aug;30(1):1-21. doi: 10.1385/MN:30:1:001. Mol Neurobiol. 2004. PMID: 15247485 Review.
The small GTPase Rab11 co-localizes with α-synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity.
Chutna O, Gonçalves S, Villar-Piqué A, Guerreiro P, Marijanovic Z, Mendes T, Ramalho J, Emmanouilidou E, Ventura S, Klucken J, Barral DC, Giorgini F, Vekrellis K, Outeiro TF. Chutna O, et al. Among authors: vekrellis k. Hum Mol Genet. 2014 Dec 20;23(25):6732-45. doi: 10.1093/hmg/ddu391. Epub 2014 Aug 4. Hum Mol Genet. 2014. PMID: 25092884
Cellular models of alpha-synuclein toxicity and aggregation.
Delenclos M, Burgess JD, Lamprokostopoulou A, Outeiro TF, Vekrellis K, McLean PJ. Delenclos M, et al. Among authors: vekrellis k. J Neurochem. 2019 Sep;150(5):566-576. doi: 10.1111/jnc.14806. Epub 2019 Jul 30. J Neurochem. 2019. PMID: 31265132 Free PMC article. Review.
72 results