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Intravenous administration of bone marrow-derived mesenchymal stem cells induces a switch from classical to atypical symptoms in experimental autoimmune encephalomyelitis.
Kurte M, Bravo-Alegría J, Torres A, Carrasco V, Ibáñez C, Vega-Letter AM, Fernández-O'Ryan C, Irarrázabal CE, Figueroa FE, Fuentealba RA, Riedel C, Carrión F. Kurte M, et al. Stem Cells Int. 2015;2015:140170. doi: 10.1155/2015/140170. Epub 2015 Mar 9. Stem Cells Int. 2015. PMID: 25838828 Free PMC article.
Overexpression of Glutamate Decarboxylase in Mesenchymal Stem Cells Enhances Their Immunosuppressive Properties and Increases GABA and Nitric Oxide Levels.
Urrutia M, Fernández S, González M, Vilches R, Rojas P, Vásquez M, Kurte M, Vega-Letter AM, Carrión F, Figueroa F, Rojas P, Irarrázabal C, Fuentealba RA. Urrutia M, et al. PLoS One. 2016 Sep 23;11(9):e0163735. doi: 10.1371/journal.pone.0163735. eCollection 2016. PLoS One. 2016. PMID: 27662193 Free PMC article.
IL17/IL17RA as a Novel Signaling Axis Driving Mesenchymal Stem Cell Therapeutic Function in Experimental Autoimmune Encephalomyelitis.
Kurte M, Luz-Crawford P, Vega-Letter AM, Contreras RA, Tejedor G, Elizondo-Vega R, Martinez-Viola L, Fernández-O'Ryan C, Figueroa FE, Jorgensen C, Djouad F, Carrión F. Kurte M, et al. Front Immunol. 2018 Apr 30;9:802. doi: 10.3389/fimmu.2018.00802. eCollection 2018. Front Immunol. 2018. PMID: 29760692 Free PMC article.
HIF1α-dependent metabolic reprogramming governs mesenchymal stem/stromal cell immunoregulatory functions.
Contreras-Lopez R, Elizondo-Vega R, Paredes MJ, Luque-Campos N, Torres MJ, Tejedor G, Vega-Letter AM, Figueroa-Valdés A, Pradenas C, Oyarce K, Jorgensen C, Khoury M, Garcia-Robles MLA, Altamirano C, Djouad F, Luz-Crawford P. Contreras-Lopez R, et al. FASEB J. 2020 Jun;34(6):8250-8264. doi: 10.1096/fj.201902232R. Epub 2020 Apr 25. FASEB J. 2020. PMID: 32333618
The ATP synthase inhibition induces an AMPK-dependent glycolytic switch of mesenchymal stem cells that enhances their immunotherapeutic potential.
Contreras-Lopez R, Elizondo-Vega R, Luque-Campos N, Torres MJ, Pradenas C, Tejedor G, Paredes-Martínez MJ, Vega-Letter AM, Campos-Mora M, Rigual-Gonzalez Y, Oyarce K, Salgado M, Jorgensen C, Khoury M, Garcia-Robles MLÁ, Altamirano C, Djouad F, Luz-Crawford P. Contreras-Lopez R, et al. Among authors: vega letter am. Theranostics. 2021 Jan 1;11(1):445-460. doi: 10.7150/thno.51631. eCollection 2021. Theranostics. 2021. PMID: 33391485 Free PMC article.
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