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Development of an AAV-based model of tauopathy targeting retinal ganglion cells and the mouse visual pathway to study the role of microglia in Tau pathology.
Duwat C, Léal P, Vautheny A, Aurégan G, Joséphine C, Gaillard MC, Hérard AS, Jan C, Gipchtein P, Mitja J, Fouquet S, Niepon ML, Hantraye P, Brouillet E, Bonvento G, Cambon K, Bemelmans AP. Duwat C, et al. Among authors: vautheny a. Neurobiol Dis. 2023 Jun 1;181:106116. doi: 10.1016/j.nbd.2023.106116. Epub 2023 Apr 11. Neurobiol Dis. 2023. PMID: 37054900 Free article.
THY-Tau22 mouse model accumulates more tauopathy at late stage of the disease in response to microglia deactivation through TREM2 deficiency.
Vautheny A, Duwat C, Aurégan G, Joséphine C, Hérard AS, Jan C, Mitja J, Gipchtein P, Gaillard MC, Buée L, Blum D, Hantraye P, Bonvento G, Brouillet E, Cambon K, Bemelmans AP. Vautheny A, et al. Neurobiol Dis. 2021 Jul;155:105398. doi: 10.1016/j.nbd.2021.105398. Epub 2021 May 18. Neurobiol Dis. 2021. PMID: 34019997 Free article.
Targeting Neuroinflammation to Treat Alzheimer's Disease.
Ardura-Fabregat A, Boddeke EWGM, Boza-Serrano A, Brioschi S, Castro-Gomez S, Ceyzériat K, Dansokho C, Dierkes T, Gelders G, Heneka MT, Hoeijmakers L, Hoffmann A, Iaccarino L, Jahnert S, Kuhbandner K, Landreth G, Lonnemann N, Löschmann PA, McManus RM, Paulus A, Reemst K, Sanchez-Caro JM, Tiberi A, Van der Perren A, Vautheny A, Venegas C, Webers A, Weydt P, Wijasa TS, Xiang X, Yang Y. Ardura-Fabregat A, et al. Among authors: vautheny a. CNS Drugs. 2017 Dec;31(12):1057-1082. doi: 10.1007/s40263-017-0483-3. CNS Drugs. 2017. PMID: 29260466 Free PMC article. Review.