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Page 1
A novel IgE-neutralizing antibody for the treatment of severe uncontrolled asthma.
Cohen ES, Dobson CL, Käck H, Wang B, Sims DA, Lloyd CO, England E, Rees DG, Guo H, Karagiannis SN, O'Brien S, Persdotter S, Ekdahl H, Butler R, Keyes F, Oakley S, Carlsson M, Briend E, Wilkinson T, Anderson IK, Monk PD, von Wachenfeldt K, Eriksson PO, Gould HJ, Vaughan TJ, May RD. Cohen ES, et al. Among authors: vaughan tj. MAbs. 2014 May-Jun;6(3):756-64. doi: 10.4161/mabs.28394. Epub 2014 Feb 28. MAbs. 2014. PMID: 24583620 Free PMC article.
Engineering a high-affinity anti-IL-15 antibody: crystal structure reveals an α-helix in VH CDR3 as key component of paratope.
Lowe DC, Gerhardt S, Ward A, Hargreaves D, Anderson M, Ferraro F, Pauptit RA, Pattison DV, Buchanan C, Popovic B, Finch DK, Wilkinson T, Sleeman M, Vaughan TJ, Mallinder PR. Lowe DC, et al. Among authors: vaughan tj. J Mol Biol. 2011 Feb 11;406(1):160-75. doi: 10.1016/j.jmb.2010.12.017. Epub 2010 Dec 16. J Mol Biol. 2011. PMID: 21167836
Whole-molecule antibody engineering: generation of a high-affinity anti-IL-6 antibody with extended pharmacokinetics.
Finch DK, Sleeman MA, Moisan J, Ferraro F, Botterell S, Campbell J, Cochrane D, Cruwys S, England E, Lane S, Rendall E, Sinha M, Walker C, Rees G, Bowen MA, Schneider A, Liang M, Faggioni R, Fung M, Mallinder PR, Wilkinson T, Kolbeck R, Vaughan T, Lowe DC. Finch DK, et al. J Mol Biol. 2011 Aug 26;411(4):791-807. doi: 10.1016/j.jmb.2011.06.031. Epub 2011 Jun 23. J Mol Biol. 2011. PMID: 21723291
Development of a homogeneous high-throughput screening assay for biological inhibitors of human rhinovirus infection.
Newton P, O'Shea D, Wells E, Moakes K, Dunmore R, Butler RJ, Wilkinson T, Ward A, Casson N, Strain M, Vousden K, Lowe DC, Pattison DV, Carruthers AM, Sleeman MA, Vaughan TJ, Harrison P. Newton P, et al. Among authors: vaughan tj. J Biomol Screen. 2013 Mar;18(3):237-46. doi: 10.1177/1087057112469047. Epub 2012 Dec 3. J Biomol Screen. 2013. PMID: 23207740
Affinity maturation of a novel antagonistic human monoclonal antibody with a long VH CDR3 targeting the Class A GPCR formyl-peptide receptor 1.
Douthwaite JA, Sridharan S, Huntington C, Hammersley J, Marwood R, Hakulinen JK, Ek M, Sjögren T, Rider D, Privezentzev C, Seaman JC, Cariuk P, Knights V, Young J, Wilkinson T, Sleeman M, Finch DK, Lowe DC, Vaughan TJ. Douthwaite JA, et al. Among authors: vaughan tj. MAbs. 2015;7(1):152-66. doi: 10.4161/19420862.2014.985158. MAbs. 2015. PMID: 25484051 Free PMC article.
139 results