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53 results

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Page 1
Optimization of Novel α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulators and the Discovery of a Preclinical Development Candidate Molecule (RGH-560).
Ledneczki I, Némethy Z, Molnár KD, Tapolcsányi P, Ilkei V, Vágó I, Kolok S, Thán M, Laszy J, Balázs O, Krámos B, Szigetvári Á, Bata I, Makó A, Visegrády A, Fodor L, Vastag M, Lévay G, Lendvai B, Greiner I, Éles J. Ledneczki I, et al. Among authors: vastag m. J Med Chem. 2023 Dec 14;66(23):16276-16302. doi: 10.1021/acs.jmedchem.3c01635. Epub 2023 Nov 21. J Med Chem. 2023. PMID: 37989278
Carbamoyloximes as novel non-competitive mGlu5 receptor antagonists.
Galambos J, Wágner G, Nógrádi K, Bielik A, Molnár L, Bobok A, Horváth A, Kiss B, Kolok S, Nagy J, Kurkó D, Bakk ML, Vastag M, Sághy K, Gyertyán I, Gál K, Greiner I, Szombathelyi Z, Keseru GM, Domány G. Galambos J, et al. Among authors: vastag m. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4371-5. doi: 10.1016/j.bmcl.2010.06.075. Epub 2010 Jun 17. Bioorg Med Chem Lett. 2010. PMID: 20615697
Quinolinyl- and phenantridinyl-acetamides as bradykinin B1 receptor antagonists.
Eles J, Beke G, Vágó I, Bozó E, Huszár J, Tarcsay A, Kolok S, Schmidt E, Vastag M, Hornok K, Farkas S, Domány G, Keserű GM. Eles J, et al. Among authors: vastag m. Bioorg Med Chem Lett. 2012 May 1;22(9):3095-9. doi: 10.1016/j.bmcl.2012.03.065. Epub 2012 Mar 21. Bioorg Med Chem Lett. 2012. PMID: 22483585
Discovery of cariprazine (RGH-188): a novel antipsychotic acting on dopamine D3/D2 receptors.
Agai-Csongor E, Domány G, Nógrádi K, Galambos J, Vágó I, Keserű GM, Greiner I, Laszlovszky I, Gere A, Schmidt E, Kiss B, Vastag M, Tihanyi K, Sághy K, Laszy J, Gyertyán I, Zájer-Balázs M, Gémesi L, Kapás M, Szombathelyi Z. Agai-Csongor E, et al. Among authors: vastag m. Bioorg Med Chem Lett. 2012 May 15;22(10):3437-40. doi: 10.1016/j.bmcl.2012.03.104. Epub 2012 Apr 4. Bioorg Med Chem Lett. 2012. PMID: 22537450
Design of novel multiple-acting ligands towards SERT and 5-HT2C receptors.
Eliás O, Agai-Csongor E, Domány G, Keserű GM, Gere A, Kiss B, Hellinger E, Vastag M, Gyertyán I. Eliás O, et al. Among authors: vastag m. Bioorg Med Chem Lett. 2014 May 1;24(9):2118-22. doi: 10.1016/j.bmcl.2014.03.043. Epub 2014 Mar 24. Bioorg Med Chem Lett. 2014. PMID: 24717153
Thieno[2,3-b]pyridines as negative allosteric modulators of metabotropic GluR5 receptors: Lead optimization.
Nógrádi K, Wágner G, Domány G, Bobok A, Magdó I, Kolok S, Mikó-Bakk ML, Vastag M, Sághy K, Gyertyán I, Kóti J, Gál K, Farkas S, Keserű GM, Greiner I, Szombathelyi Z. Nógrádi K, et al. Among authors: vastag m. Bioorg Med Chem Lett. 2015 Apr 15;25(8):1724-1729. doi: 10.1016/j.bmcl.2015.02.073. Epub 2015 Mar 7. Bioorg Med Chem Lett. 2015. PMID: 25791451
The influence of 5-HT(2A) activity on a 5-HT(2C) specific in vivo assay used for early identification of multiple acting SERT and 5-HT(2C) receptor ligands.
Éliás O, Nógrádi K, Domány G, Szakács Z, Kóti J, Szántay C Jr, Tarcsay Á, Keserű GM, Gere A, Kiss B, Kurkó D, Kolok S, Némethy Z, Kapui Z, Hellinger É, Vastag M, Sághy K, Kedves R, Gyertyán I. Éliás O, et al. Among authors: vastag m. Bioorg Med Chem Lett. 2016 Feb 1;26(3):914-920. doi: 10.1016/j.bmcl.2015.12.071. Epub 2015 Dec 21. Bioorg Med Chem Lett. 2016. PMID: 26748694
4-Aryl-3-arylsulfonyl-quinolines as negative allosteric modulators of metabotropic GluR5 receptors: From HTS hit to development candidate.
Galambos J, Domány G, Nógrádi K, Wágner G, Keserű GM, Bobok A, Kolok S, Mikó-Bakk ML, Vastag M, Sághy K, Kóti J, Szakács Z, Béni Z, Gál K, Szombathelyi Z, Greiner I. Galambos J, et al. Among authors: vastag m. Bioorg Med Chem Lett. 2016 Feb 15;26(4):1249-52. doi: 10.1016/j.bmcl.2016.01.024. Epub 2016 Jan 11. Bioorg Med Chem Lett. 2016. PMID: 26774652
53 results