Varma M - Search Results

1

Physiologically-Based Pharmacokinetic Models for Evaluating Membrane Transporter Mediated Drug-Drug Interactions: Current Capabilities, Case Studies, Future Opportunities, and Recommendations.

Taskar KS, Pilla Reddy V, Burt H, Posada MM, Varma M, Zheng M, Ullah M, Emami Riedmaier A, Umehara KI, Snoeys J, Nakakariya M, Chu X, Beneton M, Chen Y, Huth F, Narayanan R, Mukherjee D, Dixit V, Sugiyama Y, Neuhoff S. Taskar KS, et al. Among authors: varma m. Clin Pharmacol Ther. 2020 May;107(5):1082-1115. doi: 10.1002/cpt.1693. Epub 2019 Dec 31. Clin Pharmacol Ther. 2020. PMID: 31628859 Free PMC article. Review.

2

Physiologically based modeling of pravastatin transporter-mediated hepatobiliary disposition and drug-drug interactions.

Varma MV, Lai Y, Feng B, Litchfield J, Goosen TC, Bergman A. Varma MV, et al. Pharm Res. 2012 Oct;29(10):2860-73. doi: 10.1007/s11095-012-0792-7. Epub 2012 May 26. Pharm Res. 2012. PMID: 22638872

3

Quantitative prediction of renal transporter-mediated clinical drug-drug interactions.

Feng B, Hurst S, Lu Y, Varma MV, Rotter CJ, El-Kattan A, Lockwood P, Corrigan B. Feng B, et al. Mol Pharm. 2013 Nov 4;10(11):4207-15. doi: 10.1021/mp400295c. Epub 2013 Oct 10. Mol Pharm. 2013. PMID: 24066726

4

Mechanism-based pharmacokinetic modeling to evaluate transporter-enzyme interplay in drug interactions and pharmacogenetics of glyburide.

Varma MV, Scialis RJ, Lin J, Bi YA, Rotter CJ, Goosen TC, Yang X. Varma MV, et al. AAPS J. 2014 Jul;16(4):736-48. doi: 10.1208/s12248-014-9614-7. Epub 2014 May 17. AAPS J. 2014. PMID: 24839071 Free PMC article.

5

In vitro and in vivo approaches to characterize transporter-mediated disposition in drug discovery.

Feng B, Varma MV, Costales C, Zhang H, Tremaine L. Feng B, et al. Expert Opin Drug Discov. 2014 Aug;9(8):873-90. doi: 10.1517/17460441.2014.922540. Epub 2014 May 24. Expert Opin Drug Discov. 2014. PMID: 24857286 Review.

6

Prediction of pharmacokinetics and drug-drug interactions when hepatic transporters are involved.

Li R, Barton HA, Varma MV. Li R, et al. Clin Pharmacokinet. 2014 Aug;53(8):659-78. doi: 10.1007/s40262-014-0156-z. Clin Pharmacokinet. 2014. PMID: 25056496 Review.

7

Quantitative prediction of transporter- and enzyme-mediated clinical drug-drug interactions of organic anion-transporting polypeptide 1B1 substrates using a mechanistic net-effect model.

Varma MV, Bi YA, Kimoto E, Lin J. Varma MV, et al. J Pharmacol Exp Ther. 2014 Oct;351(1):214-23. doi: 10.1124/jpet.114.215970. Epub 2014 Aug 8. J Pharmacol Exp Ther. 2014. PMID: 25107633

8

Dealing with the complex drug-drug interactions: towards mechanistic models.

Varma MV, Pang KS, Isoherranen N, Zhao P. Varma MV, et al. Biopharm Drug Dispos. 2015 Mar;36(2):71-92. doi: 10.1002/bdd.1934. Epub 2015 Feb 10. Biopharm Drug Dispos. 2015. PMID: 25545151 Review.

9

Evaluation and Quantitative Prediction of Renal Transporter-Mediated Drug-Drug Interactions.

Feng B, Varma MV. Feng B, et al. J Clin Pharmacol. 2016 Jul;56 Suppl 7:S110-21. doi: 10.1002/jcph.702. J Clin Pharmacol. 2016. PMID: 27385169 Review.

10

Transporter-Enzyme Interplay: Deconvoluting Effects of Hepatic Transporters and Enzymes on Drug Disposition Using Static and Dynamic Mechanistic Models.

Varma MV, El-Kattan AF. Varma MV, et al. J Clin Pharmacol. 2016 Jul;56 Suppl 7:S99-S109. doi: 10.1002/jcph.695. J Clin Pharmacol. 2016. PMID: 27385183 Review.

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