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Structural Basis for Achieving GSK-3β Inhibition with High Potency, Selectivity, and Brain Exposure for Positron Emission Tomography Imaging and Drug Discovery.
Bernard-Gauthier V, Mossine AV, Knight A, Patnaik D, Zhao WN, Cheng C, Krishnan HS, Xuan LL, Chindavong PS, Reis SA, Chen JM, Shao X, Stauff J, Arteaga J, Sherman P, Salem N, Bonsall D, Amaral B, Varlow C, Wells L, Martarello L, Patel S, Liang SH, Kurumbail RG, Haggarty SJ, Scott PJH, Vasdev N. Bernard-Gauthier V, et al. Among authors: varlow c. J Med Chem. 2019 Nov 14;62(21):9600-9617. doi: 10.1021/acs.jmedchem.9b01030. Epub 2019 Oct 21. J Med Chem. 2019. PMID: 31535859 Free PMC article.
Fluorine-18: an untapped resource in inorganic chemistry.
Varlow C , Szames D , Dahl K , Bernard-Gauthier V , Vasdev N . Varlow C , et al. Chem Commun (Camb). 2018 Oct 18;54(84):11835-11842. doi: 10.1039/c8cc04751k. Chem Commun (Camb). 2018. PMID: 30191929 Free PMC article.
Positron Emission Tomography Imaging of the Endocannabinoid System: Opportunities and Challenges in Radiotracer Development.
Hou L, Rong J, Haider A, Ogasawara D, Varlow C, Schafroth MA, Mu L, Gan J, Xu H, Fowler CJ, Zhang MR, Vasdev N, Ametamey S, Cravatt BF, Wang L, Liang SH. Hou L, et al. Among authors: varlow c. J Med Chem. 2021 Jan 14;64(1):123-149. doi: 10.1021/acs.jmedchem.0c01459. Epub 2020 Dec 30. J Med Chem. 2021. PMID: 33379862 Free PMC article. Review.
In Vitro Evaluation of [3H]CPPC as a Tool Radioligand for CSF-1R.
Knight AC, Varlow C, Zi T, Liang SH, Josephson L, Schmidt K, Patel S, Vasdev N. Knight AC, et al. Among authors: varlow c. ACS Chem Neurosci. 2021 Mar 17;12(6):998-1006. doi: 10.1021/acschemneuro.0c00802. Epub 2021 Mar 5. ACS Chem Neurosci. 2021. PMID: 33667059 Free PMC article.
13 results