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Discovery and characterization of novel indole and 7-azaindole derivatives as inhibitors of β-amyloid-42 aggregation for the treatment of Alzheimer's disease.
Bioorg Med Chem Lett. 2017 Mar 15;27(6):1405-1411. doi: 10.1016/j.bmcl.2017.02.001. Epub 2017 Feb 4.
Bioorg Med Chem Lett. 2017.
PMID: 28216401
Discovery and structure activity relationship of small molecule inhibitors of toxic β-amyloid-42 fibril formation.
Kroth H, Ansaloni A, Varisco Y, Jan A, Sreenivasachary N, Rezaei-Ghaleh N, Giriens V, Lohmann S, López-Deber MP, Adolfsson O, Pihlgren M, Paganetti P, Froestl W, Nagel-Steger L, Willbold D, Schrader T, Zweckstetter M, Pfeifer A, Lashuel HA, Muhs A.
Kroth H, et al. Among authors: varisco y.
J Biol Chem. 2012 Oct 5;287(41):34786-800. doi: 10.1074/jbc.M112.357665. Epub 2012 Aug 13.
J Biol Chem. 2012.
PMID: 22891248
Free PMC article.
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Synthesis and structure-activity relationship of 2,6-disubstituted pyridine derivatives as inhibitors of β-amyloid-42 aggregation.
Kroth H, Sreenivasachary N, Hamel A, Benderitter P, Varisco Y, Giriens V, Paganetti P, Froestl W, Pfeifer A, Muhs A.
Kroth H, et al. Among authors: varisco y.
Bioorg Med Chem Lett. 2016 Jul 15;26(14):3330-3335. doi: 10.1016/j.bmcl.2016.05.040. Epub 2016 May 13.
Bioorg Med Chem Lett. 2016.
PMID: 27256911
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Discovery of 2-(4-(2-fluoroethoxy)piperidin-1-yl)-9-methyl-9H-pyrrolo[2,3-b:4,5-c']dipyridine ([18F]PI-2014) as PET tracer for the detection of pathological aggregated tau in Alzheimer's disease and other tauopathies.
Gabellieri E, Capotosti F, Molette J, Sreenivasachary N, Mueller A, Berndt M, Schieferstein H, Juergens T, Varisco Y, Oden F, Schmitt-Willich H, Hickman D, Dinkelborg L, Stephens A, Pfeifer A, Kroth H.
Gabellieri E, et al. Among authors: varisco y.
Eur J Med Chem. 2020 Oct 15;204:112615. doi: 10.1016/j.ejmech.2020.112615. Epub 2020 Jul 15.
Eur J Med Chem. 2020.
PMID: 32771872
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Discovery and preclinical characterization of [18F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer's disease and other tauopathies.
Kroth H, Oden F, Molette J, Schieferstein H, Capotosti F, Mueller A, Berndt M, Schmitt-Willich H, Darmency V, Gabellieri E, Boudou C, Juergens T, Varisco Y, Vokali E, Hickman DT, Tamagnan G, Pfeifer A, Dinkelborg L, Muhs A, Stephens A.
Kroth H, et al. Among authors: varisco y.
Eur J Nucl Med Mol Imaging. 2019 Sep;46(10):2178-2189. doi: 10.1007/s00259-019-04397-2. Epub 2019 Jul 1.
Eur J Nucl Med Mol Imaging. 2019.
PMID: 31264169
Free PMC article.
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An effector-reduced anti-β-amyloid (Aβ) antibody with unique aβ binding properties promotes neuroprotection and glial engulfment of Aβ.
Adolfsson O, Pihlgren M, Toni N, Varisco Y, Buccarello AL, Antoniello K, Lohmann S, Piorkowska K, Gafner V, Atwal JK, Maloney J, Chen M, Gogineni A, Weimer RM, Mortensen DL, Friesenhahn M, Ho C, Paul R, Pfeifer A, Muhs A, Watts RJ.
Adolfsson O, et al. Among authors: varisco y.
J Neurosci. 2012 Jul 11;32(28):9677-89. doi: 10.1523/JNEUROSCI.4742-11.2012.
J Neurosci. 2012.
PMID: 22787053
Free PMC article.
Clinical Trial.
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