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Design and structural validation of peptide-drug conjugate ligands of the kappa-opioid receptor.
Muratspahić E, Deibler K, Han J, Tomašević N, Jadhav KB, Olivé-Marti AL, Hochrainer N, Hellinger R, Koehbach J, Fay JF, Rahman MH, Hegazy L, Craven TW, Varga BR, Bhardwaj G, Appourchaux K, Majumdar S, Muttenthaler M, Hosseinzadeh P, Craik DJ, Spetea M, Che T, Baker D, Gruber CW. Muratspahić E, et al. Among authors: varga br. Nat Commun. 2023 Dec 6;14(1):8064. doi: 10.1038/s41467-023-43718-w. Nat Commun. 2023. PMID: 38052802 Free PMC article.
Structure-based design of bitopic ligands for the µ-opioid receptor.
Faouzi A, Wang H, Zaidi SA, DiBerto JF, Che T, Qu Q, Robertson MJ, Madasu MK, El Daibani A, Varga BR, Zhang T, Ruiz C, Liu S, Xu J, Appourchaux K, Slocum ST, Eans SO, Cameron MD, Al-Hasani R, Pan YX, Roth BL, McLaughlin JP, Skiniotis G, Katritch V, Kobilka BK, Majumdar S. Faouzi A, et al. Among authors: varga br. Nature. 2023 Jan;613(7945):767-774. doi: 10.1038/s41586-022-05588-y. Epub 2022 Nov 30. Nature. 2023. PMID: 36450356 Free PMC article.
Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site.
Uprety R, Che T, Zaidi SA, Grinnell SG, Varga BR, Faouzi A, Slocum ST, Allaoa A, Varadi A, Nelson M, Bernhard SM, Kulko E, Le Rouzic V, Eans SO, Simons CA, Hunkele A, Subrath J, Pan YX, Javitch JA, McLaughlin JP, Roth BL, Pasternak GW, Katritch V, Majumdar S. Uprety R, et al. Among authors: varga br. Elife. 2021 Feb 8;10:e56519. doi: 10.7554/eLife.56519. Elife. 2021. PMID: 33555255 Free PMC article.
Biased Opioid Ligands.
Faouzi A, Varga BR, Majumdar S. Faouzi A, et al. Among authors: varga br. Molecules. 2020 Sep 16;25(18):4257. doi: 10.3390/molecules25184257. Molecules. 2020. PMID: 32948048 Free PMC article. Review.
Inversion of Configuration at the Phosphorus Nucleophile in the Diastereoselective and Enantioselective Synthesis of P-Stereogenic syn-Phosphiranes from Chiral Epoxides.
Muldoon JA, Varga BR, Deegan MM, Chapp TW, Eördögh ÁM, Hughes RP, Glueck DS, Moore CE, Rheingold AL. Muldoon JA, et al. Among authors: varga br. Angew Chem Int Ed Engl. 2018 Apr 23;57(18):5047-5051. doi: 10.1002/anie.201801427. Epub 2018 Mar 23. Angew Chem Int Ed Engl. 2018. PMID: 29484790
15 results