Varela MT - Search Results

1

Optimization of physicochemical properties is a strategy to improve drug-likeness associated with activity: Novel active and selective compounds against Trypanosoma cruzi.

Varela MT, Amaral M, Romanelli MM, de Castro Levatti EV, Tempone AG, Fernandes JPS. Varela MT, et al. Eur J Pharm Sci. 2022 Apr 1;171:106114. doi: 10.1016/j.ejps.2021.106114. Epub 2022 Jan 2. Eur J Pharm Sci. 2022. PMID: 34986415 Free article.

2

Gibbilimbol analogues as antiparasitic agents--Synthesis and biological activity against Trypanosoma cruzi and Leishmania (L.) infantum.

Varela MT, Dias RZ, Martins LF, Ferreira DD, Tempone AG, Ueno AK, Lago JH, Fernandes JP. Varela MT, et al. Bioorg Med Chem Lett. 2016 Feb 15;26(4):1180-3. doi: 10.1016/j.bmcl.2016.01.040. Epub 2016 Jan 16. Bioorg Med Chem Lett. 2016. PMID: 26821820

3

New alkenyl derivative from Piper malacophyllum and analogues: Antiparasitic activity against Trypanosoma cruzi and Leishmania infantum.

Varela MT, Lima ML, Galuppo MK, Tempone AG, de Oliveira A, Lago JHG, Fernandes JPS. Varela MT, et al. Chem Biol Drug Des. 2017 Nov;90(5):1007-1011. doi: 10.1111/cbdd.12986. Epub 2017 May 3. Chem Biol Drug Des. 2017. PMID: 28371557

4

Natural Products: Key Prototypes to Drug Discovery Against Neglected Diseases Caused by Trypanosomatids.

Varela MT, Fernandes JPS. Varela MT, et al. Curr Med Chem. 2020;27(13):2133-2146. doi: 10.2174/0929867325666180501102450. Curr Med Chem. 2020. PMID: 29714138 Review.

5

Antiparasitic activity of new gibbilimbol analogues and SAR analysis through efficiency and statistical methods.

Varela MT, Romaneli MM, Lima ML, Borborema SET, Tempone AG, Fernandes JPS. Varela MT, et al. Eur J Pharm Sci. 2018 Sep 15;122:31-41. doi: 10.1016/j.ejps.2018.06.023. Epub 2018 Jun 21. Eur J Pharm Sci. 2018. PMID: 29935351

6

Pyrazinoates as antiparasitic agents against Trypanosoma cruzi.

Vasconcelos CI, Varela MT, Torrecilhas AC, Fernandes JPS. Vasconcelos CI, et al. Among authors: varela mt. Arch Pharm (Weinheim). 2018 Nov;351(11):e1800190. doi: 10.1002/ardp.201800190. Epub 2018 Oct 9. Arch Pharm (Weinheim). 2018. PMID: 30298951

7

Evaluation of the antitrypanosoma activity and SAR study of novel LINS03 derivatives.

Varela MT, Costa-Silva TA, Lago JHG, Tempone AG, Fernandes JPS. Varela MT, et al. Bioorg Chem. 2019 Aug;89:102996. doi: 10.1016/j.bioorg.2019.102996. Epub 2019 May 18. Bioorg Chem. 2019. PMID: 31132603

8

Improving the drug-likeness of inspiring natural products - evaluation of the antiparasitic activity against Trypanosoma cruzi through semi-synthetic and simplified analogues of licarin A.

Morais TR, Conserva GAA, Varela MT, Costa-Silva TA, Thevenard F, Ponci V, Fortuna A, Falcão AC, Tempone AG, Fernandes JPS, Lago JHG. Morais TR, et al. Among authors: varela mt. Sci Rep. 2020 Mar 25;10(1):5467. doi: 10.1038/s41598-020-62352-w. Sci Rep. 2020. PMID: 32214193 Free PMC article.

9

Coumaric acid analogues inhibit growth and melanin biosynthesis in Cryptococcus neoformans and potentialize amphotericin B antifungal activity.

Oliveira L, Ferrarini M, Dos Santos AP, Varela MT, Corrêa ITS, Tempone AG, Melhem MSC, Vallim MA, Fernandes JPS, Pascon RC. Oliveira L, et al. Among authors: varela mt. Eur J Pharm Sci. 2020 Oct 1;153:105473. doi: 10.1016/j.ejps.2020.105473. Epub 2020 Jul 18. Eur J Pharm Sci. 2020. PMID: 32693012

10

Coumaric acid derivatives as tyrosinase inhibitors: Efficacy studies through in silico, in vitro and ex vivo approaches.

Varela MT, Ferrarini M, Mercaldi VG, Sufi BDS, Padovani G, Nazato LIS, Fernandes JPS. Varela MT, et al. Bioorg Chem. 2020 Oct;103:104108. doi: 10.1016/j.bioorg.2020.104108. Epub 2020 Jul 21. Bioorg Chem. 2020. PMID: 32750608

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