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EB1- and EB2-dependent anterograde trafficking of TRPM4 regulates focal adhesion turnover and cell invasion.
Blanco C, Morales D, Mogollones I, Vergara-Jaque A, Vargas C, Álvarez A, Riquelme D, Leiva-Salcedo E, González W, Morales D, Maureira D, Aldunate I, Cáceres M, Varela D, Cerda O. Blanco C, et al. Among authors: varela d. FASEB J. 2019 Aug;33(8):9434-9452. doi: 10.1096/fj.201900136R. Epub 2019 May 21. FASEB J. 2019. PMID: 31112396
Finally, we demonstrated that the expression of a soluble fragment containing the EB binding motif of TRPM4 reduces the plasma membrane expression of the channel and affects TRPM4-dependent focal adhesion disassembly and cell invasion processes.-Blanco, C., Morales, D., Mo …
Finally, we demonstrated that the expression of a soluble fragment containing the EB binding motif of TRPM4 reduces the plasma membrane expr …
Increases in reactive oxygen species enhance vascular endothelial cell migration through a mechanism dependent on the transient receptor potential melastatin 4 ion channel.
Sarmiento D, Montorfano I, Cerda O, Cáceres M, Becerra A, Cabello-Verrugio C, Elorza AA, Riedel C, Tapia P, Velásquez LA, Varela D, Simon F. Sarmiento D, et al. Among authors: varela d. Microvasc Res. 2015 Mar;98:187-96. doi: 10.1016/j.mvr.2014.02.001. Epub 2014 Feb 9. Microvasc Res. 2015. PMID: 24518820
TRPM4 Is a Novel Component of the Adhesome Required for Focal Adhesion Disassembly, Migration and Contractility.
Cáceres M, Ortiz L, Recabarren T, Romero A, Colombo A, Leiva-Salcedo E, Varela D, Rivas J, Silva I, Morales D, Campusano C, Almarza O, Simon F, Toledo H, Park KS, Trimmer JS, Cerda O. Cáceres M, et al. Among authors: varela d. PLoS One. 2015 Jun 25;10(6):e0130540. doi: 10.1371/journal.pone.0130540. eCollection 2015. PLoS One. 2015. PMID: 26110647 Free PMC article.
FR58P1a; a new uncoupler of OXPHOS that inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/β1-integrin pathway.
Urra FA, Muñoz F, Córdova-Delgado M, Ramírez MP, Peña-Ahumada B, Rios M, Cruz P, Ahumada-Castro U, Bustos G, Silva-Pavez E, Pulgar R, Morales D, Varela D, Millas-Vargas JP, Retamal E, Ramírez-Rodríguez O, Pessoa-Mahana H, Pavani M, Ferreira J, Cárdenas C, Araya-Maturana R. Urra FA, et al. Among authors: varela d. Sci Rep. 2018 Sep 4;8(1):13190. doi: 10.1038/s41598-018-31367-9. Sci Rep. 2018. PMID: 30181620 Free PMC article.
146 results